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well welcome everyone this is rick

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woychik the director of NIEHS and i want

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to welcome

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everyone to the 162nd meeting of the

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national advisory environmental health

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sciences council

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so i will have my virtual gavel

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and i have just started the meeting so i

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also want to say that pursuant to the

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government in the sunshine act

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all aspects of this meeting are open to

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the public except the review

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discussion and evaluation of grant

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applications

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and related information so

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with that introduction pat i think i'm

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turning over the

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the virtual platform to you

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all right thank you rick um welcome

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everyone

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as rick i said glad to have you here um

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we want to start as we always do by

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going around the virtual table and uh in

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letting the council members and our

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senior leadership members um

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introduce themselves i will call your

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name and then i will ask you to you know

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say who you are and what your

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affiliation is so starting with council

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members

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jose can you introduce yourself please

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good morning i'm jose cordeiro

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from the university of georgia thank you

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uh lynn good morning i am lynn goldman

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and i am

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dean at the milken institute school of

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public health at the george washington

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university hi everyone

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thanks um irva i think i saw you on are

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you with us

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yes i am ah there you are hi herba herze

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picciotto university of california davis

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i direct the environmental health

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sciences center

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and shook me home are you available yes

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i am

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mae hall university of arkansas for

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medical sciences

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thank you um terry

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terry cavanaugh university of washington

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and director of our edge

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edge center terrific uh katrina

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katrina korffmacher i'm the community

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engagement core director at the

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environmental health sciences center at

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the university of rochester

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thank you eva i'm edith parker i'm dean

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of the

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college of public health at the

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university of iowa

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marla marla perez logo professor of

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environmental sociology at

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the university of puerto rico mayaguez

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and now visiting professor at macalester

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college

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thank you um trevor trevor penning from

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the university of pennsylvania i direct

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our p30 environmental health sciences

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call center

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okay thank you brad brad we're set

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washington university school of medicine

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okay um sue

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dr shenz hi sue schatz

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uh beckman institute for advanced

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science and technology at the university

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of illinois at urbana champaign

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thank you um andy she

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hi andy sure autism speaks thank you

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um uh patrick simon patrick sung

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i'm a professor of biochemistry and

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structural biology

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at the university of texas health

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science center san antonio

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thank you robin robin tangway oregon

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state university

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um jalon good morning jalon white news

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some founder of empowering a green

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environment and economy

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llc thank you and bob

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bob wright chair of environmental

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medicine mount sinai school of medicine

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terrific thank you and now our ex

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official members bill

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good morning it's bill cebulas i serve

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ex officio representing cdc

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and atsdr and

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um suzanne suzanne fitzpatrick

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u.s food and drug administration thank

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you and do we have andy geller on

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not yet okay terrific thank you and now

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um

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i would like to uh the senior leadership

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to introduce itself gwen are you

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with us good morning glenn coleman

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acting deputy director at iehs

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and daryl i am daryl zelden scientific

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director dir

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thank you uh brian hi i'm brian barrage

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i'm the scientific director for the

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division of the national toxicology

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program

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and do we have jan on

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okay um and then chris

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long was here a minute ago

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that jan should be on i

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hope if she if she's on just on mute and

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you can introduce yourself

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okay i'm not seeing her on the list but

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i did see chris

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are you there chris i just had to step

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off

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um anybody from senior leadership oh

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gary i'm sorry yes

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dr allison sorry good morning everyone

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i'm gary ellison i'm acting director of

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the division of extramural research and

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training

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in iehs all right have i called everyone

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who's on senior leadership

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don't miss anyone terrific okay well

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thank you everyone

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um rick i'm going to turn it back over

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you for a special introduction

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great thanks pat so i would like to

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introduce bill elwood

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who is a health science administrator in

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the office of behavioral and social

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sciences research obssr

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so he facilitates nih's basic behavioral

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and social science opportunity network

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so

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bill are you on the zoo

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yes sir thanks rick happy to be with you

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terrific great to have you with us okay

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so pat do we go around the table and and

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others who are on uh introduce himself

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or do we move on

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we move on um you're now up to the um

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the next step here i understand that

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there are some

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retiring members of council so i'd like

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to acknowledge the service of dr jose

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cordeiro

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shook me ho suzanne shenz

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andy she and patrick sung so thank you

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all

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for your dedicated service to council

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over the course of the last uh four

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years

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uh it seems like yesterday but we were

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just welcoming you on council

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so because of the transition of course

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uh your your certificates will be

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mailed to you at a later date so uh

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just i want to express my appreciation

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for the time the effort that you put

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into helping us on council so

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okay pat back to you

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sorry just a few housekeeping things

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here um

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first i want to remind everyone that um

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we will be having a working lunch today

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because

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of the fact that we're spread out coast

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to coast and

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um finding an appropriate lunch period

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was difficult

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what we will do is we'll take a

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15-minute break um in the middle of

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the meeting today give you a chance to

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go grab your sandwich or salad whatever

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and bring it back and we will

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have like i say the working lunch um so

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we will

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be back within 15 minutes of you

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um i would typically at this point be

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telling you like where the cafeteria is

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for me it's right over here uh the

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restrooms well whatever

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um just a reminder of some of the uh

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virtual meeting etiquette while you're

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not speaking

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please mute your microphone and turn

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your video off try to save bandwidth

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if you want to speak you can raise your

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hand virtually or literally

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um or you can put a note in the chat

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saying um that you would like to speak

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um but if force comes to worst if you

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don't get called on just go ahead and

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talk

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i would rather that you have be heard

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than us be too polite

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i should let you know that we remind you

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that this is a public meeting we're

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being webcast and so the public

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will be hearing us members of the public

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who want to express views

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regarding anything we're talking about

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can do so uh

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via a the email that is on our niehs

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webpage

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we will have one vote today for a

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concept that will be conducted

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electronically via the council book like

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we did during the closed session

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the next step for us is to is

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consideration of the september 2020

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meeting um council meeting minutes these

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meetings

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excuse me these minutes are available on

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the uh

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nae hs council webpage and council

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members also have them in their ecb

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so hopefully you have time to review

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them

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at this point i need a motion to approve

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the minutes from last

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council meeting if i can have a council

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member

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make that motion please and i can't see

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you so move so

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moved okay thank you um

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and i said got a second and got any

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second any discussions

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no if not um liz i believe they can vote

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on this through the council book is that

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right

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i can't see you on the on the zoom list

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so you'll have to but there you are i

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can't see you all right

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we're just waiting for everyone to vote

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and liz you'll let me know when the

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voting is complete

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you're muted

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okay so voting is complete okay i'll

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take that as it is thank you all

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um the next thing i'll just mention in

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the

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information we sent you are the future

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uh

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council meetings our next one is june

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1st uh and second

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at this point it will at this point it

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will be a virtual meeting

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um the september council meeting the

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fourth and 14th and 15th of september

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um a decision hasn't been made about

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whether that will be virtual or

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face-to-face moving and with that

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um i will finish up the business

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part of this and rick i guess i will

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introduce our first our next which is

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the uh

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concept um we have

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okay we have sri natador who will be

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speaking now

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um when we have um new programs or

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programs that we're looking to review

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every five years or so we have the

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program officer come to council

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and present um and uh ask for a present

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the concept

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and we'll ask for your approval at the

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end so shari will make his presentation

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at the end of that time i'll call for a

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vote

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so sri if you're ready um and john can

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you

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get us going yeah um thanks pat

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um good morning um thank you for the

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opportunity to share with you

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this concept to promote fundamental

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research

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in support of the transcendent

288
00:11:06.560 --> 00:11:08.540
countermeasures against chemical threat

289
00:11:08.560 --> 00:11:11.340
agents program which we abbreviate as

290
00:11:11.360 --> 00:11:11.900
counter

291
00:11:11.920 --> 00:11:14.140
act program sometimes my counteract

292
00:11:14.160 --> 00:11:15.900
pronunciation will be

293
00:11:15.920 --> 00:11:18.460
sounding like a contract excuse me it is

294
00:11:18.480 --> 00:11:21.180
the counter act program

295
00:11:21.200 --> 00:11:25.340
this concept did i get the

296
00:11:25.360 --> 00:11:30.780
opportunity to move this lives

297
00:11:30.800 --> 00:11:32.300
sheree we're getting some notes here

298
00:11:32.320 --> 00:11:34.300
that they can't see your slides

299
00:11:34.320 --> 00:11:37.250
so i can see the slides i can see them

300
00:11:37.270 --> 00:11:38.460
too i see them

301
00:11:38.480 --> 00:11:42.050
i've seen them okay i see them too

302
00:11:42.070 --> 00:11:44.300
so i um so david i'm not sure what's

303
00:11:44.320 --> 00:11:45.490
happening on your end

304
00:11:45.510 --> 00:11:47.740
sri did you click on the on your slide

305
00:11:47.760 --> 00:11:51.180
single click twice in a row

306
00:11:51.200 --> 00:11:54.810
there you go there you go yeah

307
00:11:54.830 --> 00:11:57.660
okay okay um

308
00:11:57.680 --> 00:11:59.740
the concept i'm going to share with you

309
00:11:59.760 --> 00:12:01.660
today is a joint effort

310
00:12:01.680 --> 00:12:04.140
with the national eye institute on

311
00:12:04.160 --> 00:12:05.810
national histology and infectious

312
00:12:05.830 --> 00:12:07.340
diseases

313
00:12:07.360 --> 00:12:11.100
um aroused from the ni

314
00:12:11.120 --> 00:12:14.460
nei and dave young from and

315
00:12:14.480 --> 00:12:16.780
ir are available on zoom if you have any

316
00:12:16.800 --> 00:12:17.810
specific questions

317
00:12:17.830 --> 00:12:20.930
on during the discussion session um

318
00:12:20.950 --> 00:12:23.660
jackie merger who recently joined our

319
00:12:23.680 --> 00:12:24.140
group

320
00:12:24.160 --> 00:12:27.180
from the intramural research program

321
00:12:27.200 --> 00:12:30.370
will be supporting this program

322
00:12:30.390 --> 00:12:33.660
in this presentation i will provide you

323
00:12:33.680 --> 00:12:34.610
a

324
00:12:34.630 --> 00:12:38.140
high level overview on the efforts

325
00:12:38.160 --> 00:12:39.980
at the federal government to address the

326
00:12:40.000 --> 00:12:42.460
public health emergency

327
00:12:42.480 --> 00:12:45.100
medical countermeasures and what's the

328
00:12:45.120 --> 00:12:45.980
role

329
00:12:46.000 --> 00:12:49.810
nih plays in this process and

330
00:12:49.830 --> 00:12:52.540
that is exclusively focused on chemical

331
00:12:52.560 --> 00:12:54.860
countermeasures

332
00:12:54.880 --> 00:12:57.180
chemical threats research program and

333
00:12:57.200 --> 00:12:58.220
i'll provide you

334
00:12:58.240 --> 00:12:59.980
what are the current opportunities

335
00:13:00.000 --> 00:13:01.250
available for

336
00:13:01.270 --> 00:13:04.370
funding through this program and we'll

337
00:13:04.390 --> 00:13:07.250
provide some examples from the existing

338
00:13:07.270 --> 00:13:08.780
research efforts within the

339
00:13:08.800 --> 00:13:11.900
pulmonary portfolio share with you some

340
00:13:11.920 --> 00:13:14.930
success stories and then what are the

341
00:13:14.950 --> 00:13:17.250
ongoing efforts within this program

342
00:13:17.270 --> 00:13:18.050
supporter

343
00:13:18.070 --> 00:13:21.810
at NIEHS and will then provide them

344
00:13:21.830 --> 00:13:23.660
what what the gaps and needs we

345
00:13:23.680 --> 00:13:24.930
identified and

346
00:13:24.950 --> 00:13:27.810
how this opportunity may contribute to

347
00:13:27.830 --> 00:13:28.700
address those

348
00:13:28.720 --> 00:13:31.340
gaps and needs and on the end i will

349
00:13:31.360 --> 00:13:33.740
want to share with you

350
00:13:33.760 --> 00:13:35.660
of information about the couple of

351
00:13:35.680 --> 00:13:37.420
upcoming meetings

352
00:13:37.440 --> 00:13:39.490
and that may be of interest to all of

353
00:13:39.510 --> 00:13:42.370
you

354
00:13:42.390 --> 00:13:46.220
so the events of the september 11 2001

355
00:13:46.240 --> 00:13:48.700
exposed the vulnerability of the united

356
00:13:48.720 --> 00:13:50.930
states to acts of terrorism

357
00:13:50.950 --> 00:13:54.540
that could employ unconventional weapons

358
00:13:54.560 --> 00:13:57.340
and tactics such as chemical biological

359
00:13:57.360 --> 00:13:59.170
radiological or nuclear

360
00:13:59.190 --> 00:14:02.610
agents against the civilian population

361
00:14:02.630 --> 00:14:06.300
so to prepare the country to handle such

362
00:14:06.320 --> 00:14:09.580
potential high consequences and public

363
00:14:09.600 --> 00:14:11.490
health emergency scenarios the

364
00:14:11.510 --> 00:14:13.340
department of

365
00:14:13.360 --> 00:14:15.900
health and human services from the

366
00:14:15.920 --> 00:14:16.610
public health

367
00:14:16.630 --> 00:14:19.020
enterprise medical public health

368
00:14:19.040 --> 00:14:20.610
emergency medical council

369
00:14:20.630 --> 00:14:23.580
measures enterprise to coordinate

370
00:14:23.600 --> 00:14:24.860
activities across

371
00:14:24.880 --> 00:14:28.050
multiple federal agencies such as the

372
00:14:28.070 --> 00:14:29.900
department of homeland security

373
00:14:29.920 --> 00:14:32.610
department of defense

374
00:14:32.630 --> 00:14:36.370
usda veteran of fives

375
00:14:36.390 --> 00:14:39.490
the this program is

376
00:14:39.510 --> 00:14:41.900
led by the assistant secretary for a

377
00:14:41.920 --> 00:14:43.810
preparedness and response

378
00:14:43.830 --> 00:14:47.580
with the core members of from

379
00:14:47.600 --> 00:14:50.780
the director of the cent cdc director of

380
00:14:50.800 --> 00:14:52.610
naid and the commissioner of

381
00:14:52.630 --> 00:14:54.540
food and drug administration serving as

382
00:14:54.560 --> 00:14:56.700
core members advising the

383
00:14:56.720 --> 00:14:59.420
assistant secretary for the preparedness

384
00:14:59.440 --> 00:15:00.860
and response

385
00:15:00.880 --> 00:15:03.980
the NIEHS place the

386
00:15:04.000 --> 00:15:07.170
foundational and essential role

387
00:15:07.190 --> 00:15:09.740
by supporting the early stage research

388
00:15:09.760 --> 00:15:11.340
towards medical countermeasures

389
00:15:11.360 --> 00:15:12.540
development

390
00:15:12.560 --> 00:15:16.700
as part of this emergency preparedness

391
00:15:16.720 --> 00:15:20.140
within nih the

392
00:15:20.160 --> 00:15:22.540
office of the biodefense research and

393
00:15:22.560 --> 00:15:25.490
security located in

394
00:15:25.510 --> 00:15:27.810
and infectious diseases who oversees

395
00:15:27.830 --> 00:15:29.420
this program

396
00:15:29.440 --> 00:15:31.420
under the umbrella of chemical

397
00:15:31.440 --> 00:15:34.050
countermeasures research program

398
00:15:34.070 --> 00:15:35.980
there are three major components within

399
00:15:36.000 --> 00:15:37.250
the countermeasure

400
00:15:37.270 --> 00:15:41.170
the ccrp program one is the counteract

401
00:15:41.190 --> 00:15:44.300
extramural researching program with the

402
00:15:44.320 --> 00:15:46.930
participation of six different ics based

403
00:15:46.950 --> 00:15:47.420
on the

404
00:15:47.440 --> 00:15:49.730
threat agents of interest and the target

405
00:15:49.750 --> 00:15:51.170
organ for example

406
00:15:51.190 --> 00:15:54.460
the ocular toxicity program is run by

407
00:15:54.480 --> 00:15:56.610
national high institute similarly the

408
00:15:56.630 --> 00:15:58.050
neurological effects

409
00:15:58.070 --> 00:16:02.300
by ninds and dermal effect toxicity by

410
00:16:02.320 --> 00:16:06.540
niams and for the pulmonary research

411
00:16:06.560 --> 00:16:07.250
program

412
00:16:07.270 --> 00:16:11.420
NIEHS is the lead the other components of

413
00:16:11.440 --> 00:16:11.810
the

414
00:16:11.830 --> 00:16:15.100
ccrp are one is an interagency agreement

415
00:16:15.120 --> 00:16:15.900
program

416
00:16:15.920 --> 00:16:18.300
with the department of defense which

417
00:16:18.320 --> 00:16:18.930
supports

418
00:16:18.950 --> 00:16:21.490
a vibrant research program at the u.s

419
00:16:21.510 --> 00:16:22.700
medical

420
00:16:22.720 --> 00:16:26.140
army research institute and also

421
00:16:26.160 --> 00:16:30.610
in this program we have a

422
00:16:30.630 --> 00:16:33.730
contract mechanism to support

423
00:16:33.750 --> 00:16:38.140
for advanced development efforts such as

424
00:16:38.160 --> 00:16:40.930
synthesis of the target compounds or

425
00:16:40.950 --> 00:16:41.660
synthesis

426
00:16:41.680 --> 00:16:44.540
of um are carrying out pharmacokinetics

427
00:16:44.560 --> 00:16:46.780
of toxicokinetic studies for the

428
00:16:46.800 --> 00:16:48.860
lead candidates identified within this

429
00:16:48.880 --> 00:16:50.140
program

430
00:16:50.160 --> 00:16:53.900
in essential this is a um

431
00:16:53.920 --> 00:16:57.020
collaborative program where nih plays

432
00:16:57.040 --> 00:16:57.420
the

433
00:16:57.440 --> 00:16:59.340
role in supporting the fundamental

434
00:16:59.360 --> 00:17:01.170
research whereas

435
00:17:01.190 --> 00:17:04.700
and border plays a support in advanced

436
00:17:04.720 --> 00:17:07.740
therapeutic developments so the success

437
00:17:07.760 --> 00:17:08.770
of the program

438
00:17:08.790 --> 00:17:11.650
is the transition of the lead candidates

439
00:17:11.670 --> 00:17:13.650
of for countermeasures identified

440
00:17:13.670 --> 00:17:15.410
through the nih program

441
00:17:15.430 --> 00:17:18.380
to the border nih also plays a critical

442
00:17:18.400 --> 00:17:19.100
role

443
00:17:19.120 --> 00:17:22.050
in in this process by facilitating

444
00:17:22.070 --> 00:17:24.380
meetings between the nih grantees

445
00:17:24.400 --> 00:17:30.370
with the boredom of scientists

446
00:17:30.390 --> 00:17:33.740


447
00:17:33.760 --> 00:17:36.060
the mission of the chemical

448
00:17:36.080 --> 00:17:38.530
countermeasures research program or ccrp

449
00:17:38.550 --> 00:17:40.940
is to accelerate development of medical

450
00:17:40.960 --> 00:17:42.460
countermeasures

451
00:17:42.480 --> 00:17:45.500
and in support of stockpiling these by

452
00:17:45.520 --> 00:17:45.980
border

453
00:17:46.000 --> 00:17:49.180
for any emergency use we

454
00:17:49.200 --> 00:17:51.650
it was initially targeted only for a

455
00:17:51.670 --> 00:17:52.860
deliberate

456
00:17:52.880 --> 00:17:56.220
effort of exposure to toxic chemicals

457
00:17:56.240 --> 00:18:00.530
and in 2005 we also included the

458
00:18:00.550 --> 00:18:02.940
any accidental public health emergency

459
00:18:02.960 --> 00:18:08.700
situations such as what we faced in them

460
00:18:08.720 --> 00:18:11.820
planet will chlorine exposure

461
00:18:11.840 --> 00:18:14.530
how the threat agents are identified for

462
00:18:14.550 --> 00:18:15.420
this program

463
00:18:15.440 --> 00:18:18.620
are the from the

464
00:18:18.640 --> 00:18:21.180
efforts by the department of homeland

465
00:18:21.200 --> 00:18:22.620
security

466
00:18:22.640 --> 00:18:25.890
where chemical threats risk assessment

467
00:18:25.910 --> 00:18:29.180
program identified about 200 chemicals

468
00:18:29.200 --> 00:18:32.220
of concern and these are the chemicals

469
00:18:32.240 --> 00:18:34.530
that can target cellular respiration

470
00:18:34.550 --> 00:18:37.180
eye skin pulmonary or neurological

471
00:18:37.200 --> 00:18:38.770
systems

472
00:18:38.790 --> 00:18:41.820
the research priorities for this program

473
00:18:41.840 --> 00:18:42.140
are

474
00:18:42.160 --> 00:18:45.010
identification of multiples of acute

475
00:18:45.030 --> 00:18:45.890
toxicity

476
00:18:45.910 --> 00:18:47.820
and identification of potential

477
00:18:47.840 --> 00:18:49.500
biomarkers

478
00:18:49.520 --> 00:18:53.340
and facilitating screening assays to

479
00:18:53.360 --> 00:18:54.380
identify

480
00:18:54.400 --> 00:18:56.770
novel or improved candidates for medical

481
00:18:56.790 --> 00:18:58.380
countermeasure

482
00:18:58.400 --> 00:19:01.180
demonstration of a target or appropriate

483
00:19:01.200 --> 00:19:01.820
biological

484
00:19:01.840 --> 00:19:04.460
activity for the candidate therapeutics

485
00:19:04.480 --> 00:19:06.700
and development use of animal models to

486
00:19:06.720 --> 00:19:11.010
demonstrate primary proof of principle

487
00:19:11.030 --> 00:19:13.100
currently this program is heavily

488
00:19:13.120 --> 00:19:14.620
focused on the

489
00:19:14.640 --> 00:19:17.100
demonstration of target and then proof

490
00:19:17.120 --> 00:19:19.010
of principle studies with the

491
00:19:19.030 --> 00:19:25.000
animal models

492
00:19:25.020 --> 00:19:28.620


493
00:19:28.640 --> 00:19:32.770
the ccrp program has an annual budget of

494
00:19:32.790 --> 00:19:34.530
about 50 million dollars which is a

495
00:19:34.550 --> 00:19:37.100
congressionally mandated program

496
00:19:37.120 --> 00:19:39.010
and this pie chart shows you the

497
00:19:39.030 --> 00:19:40.700
distribution of

498
00:19:40.720 --> 00:19:43.100
funds across different target agents and

499
00:19:43.120 --> 00:19:44.300
different

500
00:19:44.320 --> 00:19:48.060
and in last year alone for the pulmonary

501
00:19:48.080 --> 00:19:48.620
program

502
00:19:48.640 --> 00:19:54.940
we invested about 20 12 million dollars

503
00:19:54.960 --> 00:19:57.980
so currently the contract research

504
00:19:58.000 --> 00:19:58.530
program

505
00:19:58.550 --> 00:20:00.770
is supported through the funding

506
00:20:00.790 --> 00:20:01.580
opportunity

507
00:20:01.600 --> 00:20:03.650
four funding opportunity mechanisms that

508
00:20:03.670 --> 00:20:04.700
are available

509
00:20:04.720 --> 00:20:08.220
one is for this forming research centers

510
00:20:08.240 --> 00:20:09.180
of excellence

511
00:20:09.200 --> 00:20:11.820
and identification of lead compounds

512
00:20:11.840 --> 00:20:13.580
optimization of lead compounds

513
00:20:13.600 --> 00:20:16.060
or in a text exploratory research

514
00:20:16.080 --> 00:20:17.340
program

515
00:20:17.360 --> 00:20:20.460
for example in the explanatory

516
00:20:20.480 --> 00:20:22.770
parent r21 program we support the

517
00:20:22.790 --> 00:20:25.010
exploration of therapeutic approaches

518
00:20:25.030 --> 00:20:27.740
or in the once you have identified a

519
00:20:27.760 --> 00:20:29.980
potential lead

520
00:20:30.000 --> 00:20:32.820
foreign and through the mechanistic

521
00:20:32.840 --> 00:20:34.620
understanding the parent

522
00:20:34.640 --> 00:20:37.740
uo one will support initial

523
00:20:37.760 --> 00:20:39.500
field relevant delivery proof of

524
00:20:39.520 --> 00:20:41.650
principle efficacy for example

525
00:20:41.670 --> 00:20:44.460
the program insists on having a

526
00:20:44.480 --> 00:20:46.060
therapeutic

527
00:20:46.080 --> 00:20:48.620
method that can be applied in the field

528
00:20:48.640 --> 00:20:49.500
situation

529
00:20:49.520 --> 00:20:51.980
of an emergency for example something

530
00:20:52.000 --> 00:20:54.060
like an ap pen that can be applied

531
00:20:54.080 --> 00:20:57.180
by intramuscular route and

532
00:20:57.200 --> 00:21:00.060
the other mechanism the uo and what we

533
00:21:00.080 --> 00:21:00.940
have

534
00:21:00.960 --> 00:21:04.220
for the optimization of lead compounds

535
00:21:04.240 --> 00:21:07.100
is this will support iterative

536
00:21:07.120 --> 00:21:09.650
structural activity relationship studies

537
00:21:09.670 --> 00:21:13.010
or effectiveness of bio

538
00:21:13.030 --> 00:21:16.060
increase the biological availability or

539
00:21:16.080 --> 00:21:16.940
absorption

540
00:21:16.960 --> 00:21:20.460
or reduce the toxicity the u54

541
00:21:20.480 --> 00:21:22.940
centers of excellence program make have

542
00:21:22.960 --> 00:21:24.060
a combination

543
00:21:24.080 --> 00:21:26.460
of either identification of your lead

544
00:21:26.480 --> 00:21:27.340
compound

545
00:21:27.360 --> 00:21:31.580
or optimization of the lead compound the

546
00:21:31.600 --> 00:21:34.700
the final goal of all these programs is

547
00:21:34.720 --> 00:21:37.650
how the leads identified and optimized

548
00:21:37.670 --> 00:21:38.860
in this program

549
00:21:38.880 --> 00:21:41.740
can transition to advanced development

550
00:21:41.760 --> 00:21:42.940
through border

551
00:21:42.960 --> 00:21:45.980
the hallmark of this program is

552
00:21:46.000 --> 00:21:48.940
how many i leads identified by the nih

553
00:21:48.960 --> 00:21:49.740
efforts

554
00:21:49.760 --> 00:21:52.770
can lead towards advanced development

555
00:21:52.790 --> 00:21:56.060
supported by bada

556
00:21:56.080 --> 00:21:58.220
currently within the pulmonary and

557
00:21:58.240 --> 00:21:59.650
ocular portfolio

558
00:21:59.670 --> 00:22:03.100
we have about 10 toxic atoms being

559
00:22:03.120 --> 00:22:03.890
studied

560
00:22:03.910 --> 00:22:06.530
the ones i marked here with astric are

561
00:22:06.550 --> 00:22:07.980
the ones that are common

562
00:22:08.000 --> 00:22:10.700
across pulmonary and ocular portfolio

563
00:22:10.720 --> 00:22:13.100
for example sulfur mustard

564
00:22:13.120 --> 00:22:15.980
acrylene on or silicons whereas

565
00:22:16.000 --> 00:22:17.980
chloropicrin is the only compound

566
00:22:18.000 --> 00:22:18.700
currently

567
00:22:18.720 --> 00:22:21.890
in the ocular portfolio or the pulmonary

568
00:22:21.910 --> 00:22:24.380
portfolio is also dominated with the

569
00:22:24.400 --> 00:22:28.060
chlorine bromine phosgene and

570
00:22:28.080 --> 00:22:31.420
other gaseous agents

571
00:22:31.440 --> 00:22:34.460
so this is a very small set of chemical

572
00:22:34.480 --> 00:22:36.460
toxic agents being pursued in this

573
00:22:36.480 --> 00:22:39.420
program currently

574
00:22:39.440 --> 00:22:41.650
let me share with you some one success

575
00:22:41.670 --> 00:22:42.460
story

576
00:22:42.480 --> 00:22:45.180
that transitions from the nih to the

577
00:22:45.200 --> 00:22:46.460
boredom

578
00:22:46.480 --> 00:22:49.340
um sulfur mustard or the mustard gas is

579
00:22:49.360 --> 00:22:50.220
a vesican

580
00:22:50.240 --> 00:22:52.220
and it's the most utilized chemical

581
00:22:52.240 --> 00:22:55.180
weapon over the last hundred years

582
00:22:55.200 --> 00:22:58.300
it is in large amounts of um sulfur

583
00:22:58.320 --> 00:22:59.420
mustard is still

584
00:22:59.440 --> 00:23:02.770
stockpiled in many countries

585
00:23:02.790 --> 00:23:06.460
with them unstable leadership

586
00:23:06.480 --> 00:23:09.650
and the for the sulfur mustard the

587
00:23:09.670 --> 00:23:12.620
in inhalation is the route of exposure

588
00:23:12.640 --> 00:23:13.100
though

589
00:23:13.120 --> 00:23:15.650
respiratory tract is the primary target

590
00:23:15.670 --> 00:23:16.620
we have

591
00:23:16.640 --> 00:23:20.820
in eyes and skin are also greatly

592
00:23:20.840 --> 00:23:24.530
affected

593
00:23:24.550 --> 00:23:26.460
i'm going to share with you what has

594
00:23:26.480 --> 00:23:29.260
been accomplished by

595
00:23:29.280 --> 00:23:31.740
the u-54 center funded at the university

596
00:23:31.760 --> 00:23:34.380
of denver colorado led by

597
00:23:34.400 --> 00:23:38.300
carl white and libya so

598
00:23:38.320 --> 00:23:41.010
based on the autopsy of the iran iraq

599
00:23:41.030 --> 00:23:43.010
war victims

600
00:23:43.030 --> 00:23:46.220
sulfur mustard poisoning demonstrated

601
00:23:46.240 --> 00:23:49.980
airway occlusions are formed with the

602
00:23:50.000 --> 00:23:53.420
fibrin clots the in the

603
00:23:53.440 --> 00:23:56.300
death is mostly due to the or these

604
00:23:56.320 --> 00:23:58.860
fibrin clots

605
00:23:58.880 --> 00:24:03.340
and inability to breathe so

606
00:24:03.360 --> 00:24:06.380
claw call white and then

607
00:24:06.400 --> 00:24:09.740
livium can simulate the similar

608
00:24:09.760 --> 00:24:12.860
occlusion of the airways with the fibrin

609
00:24:12.880 --> 00:24:14.620
clots in their

610
00:24:14.640 --> 00:24:18.380
sulfur mustard and morphology rat model

611
00:24:18.400 --> 00:24:21.740
and demonstrated sub fibrin clots

612
00:24:21.760 --> 00:24:25.100
both in the major highways and in the

613
00:24:25.120 --> 00:24:26.860
dependent highways

614
00:24:26.880 --> 00:24:30.130
arrays as you see here with the

615
00:24:30.150 --> 00:24:33.340
cash scores so

616
00:24:33.360 --> 00:24:35.740
they explored whether tissue plastinogen

617
00:24:35.760 --> 00:24:36.460
actor

618
00:24:36.480 --> 00:24:38.860
activator or tpa which is a potent

619
00:24:38.880 --> 00:24:41.340
fibrolytic agent currently

620
00:24:41.360 --> 00:24:43.740
fda approved for intravascular clot

621
00:24:43.760 --> 00:24:45.180
lysis

622
00:24:45.200 --> 00:24:48.300
in stroke and heart attack as a under

623
00:24:48.320 --> 00:24:49.740
emergency youth also

624
00:24:49.760 --> 00:24:52.770
emergency use authorization so

625
00:24:52.790 --> 00:24:55.420
when they explored the by introductively

626
00:24:55.440 --> 00:24:58.300
administering the tpa to these threats

627
00:24:58.320 --> 00:25:00.700
they could see a hundred percent survive

628
00:25:00.720 --> 00:25:01.500
of the

629
00:25:01.520 --> 00:25:06.220
sulfur mustard exposed rats in 48 hours

630
00:25:06.240 --> 00:25:10.060
this program is now currently

631
00:25:10.080 --> 00:25:13.250
in advanced development by evaluating

632
00:25:13.270 --> 00:25:16.620
the feather similar vibrant cross can be

633
00:25:16.640 --> 00:25:19.180
hydrolyzed with the tpa administration

634
00:25:19.200 --> 00:25:21.340
in a large animal model

635
00:25:21.360 --> 00:25:24.460
in collaboration with genetic tech

636
00:25:24.480 --> 00:25:27.010
there are two other compound elites

637
00:25:27.030 --> 00:25:28.940
identified within the

638
00:25:28.960 --> 00:25:32.060
pulmonary program supported by NIEHS have

639
00:25:32.080 --> 00:25:33.100
also

640
00:25:33.120 --> 00:25:36.940
transitioned to the body one is

641
00:25:36.960 --> 00:25:42.930
within trip four in channel blocker it

642
00:25:42.950 --> 00:25:44.770


643
00:25:44.790 --> 00:25:48.860
is currently on advanced development

644
00:25:48.880 --> 00:25:51.250
by border support in collaboration with

645
00:25:51.270 --> 00:25:52.530
gs game

646
00:25:52.550 --> 00:25:55.580
and another all and an

647
00:25:55.600 --> 00:25:58.940
agent for the bifunctional nitric oxide

648
00:25:58.960 --> 00:25:59.740
donor

649
00:25:59.760 --> 00:26:01.740
agent developed by the radical

650
00:26:01.760 --> 00:26:02.860
therapeutics

651
00:26:02.880 --> 00:26:06.460
also for chlorine induced injuries

652
00:26:06.480 --> 00:26:09.250
over the period about eight of the leads

653
00:26:09.270 --> 00:26:09.980
compound

654
00:26:10.000 --> 00:26:12.300
have been transitioned from this program

655
00:26:12.320 --> 00:26:13.820
three for the new rule

656
00:26:13.840 --> 00:26:16.060
one for ocular and the rest for the

657
00:26:16.080 --> 00:26:18.710
pulmonary portfolio

658
00:26:18.730 --> 00:26:22.460
[Music]

659
00:26:22.480 --> 00:26:24.940
i want to share with you the couple of

660
00:26:24.960 --> 00:26:26.300
um

661
00:26:26.320 --> 00:26:29.340
studies within this program um

662
00:26:29.360 --> 00:26:32.530
i'm sure many of you remember

663
00:26:32.550 --> 00:26:35.500
the one of the worst industrial

664
00:26:35.520 --> 00:26:38.220
disasters happened in 1984

665
00:26:38.240 --> 00:26:41.340
in bhopal india where

666
00:26:41.360 --> 00:26:43.890
a huge quantities of methyl isocyanate

667
00:26:43.910 --> 00:26:46.380
was accidentally exposed

668
00:26:46.400 --> 00:26:49.580
that led to almost 11 000 mortality

669
00:26:49.600 --> 00:26:52.940
acute mortalities above and still half a

670
00:26:52.960 --> 00:26:53.890
million people

671
00:26:53.910 --> 00:26:56.220
suffering from different diseases

672
00:26:56.240 --> 00:26:58.700
associated with exposure to

673
00:26:58.720 --> 00:27:02.380
methyl isocyanate carl white's group

674
00:27:02.400 --> 00:27:04.130
again at the university of denver

675
00:27:04.150 --> 00:27:06.060
colorado center

676
00:27:06.080 --> 00:27:09.420
are exploring two hypotheses

677
00:27:09.440 --> 00:27:11.820
to find a countermeasure for methyl

678
00:27:11.840 --> 00:27:14.060
isocyanate poisoning

679
00:27:14.080 --> 00:27:17.500
when the methyl isocyanate exposure

680
00:27:17.520 --> 00:27:20.860
leads to cellular depletion of thial

681
00:27:20.880 --> 00:27:21.650
groups

682
00:27:21.670 --> 00:27:24.370
due to carbon myelation of thiols and

683
00:27:24.390 --> 00:27:26.300
also they found the inhibition of the

684
00:27:26.320 --> 00:27:27.530
thyroid active

685
00:27:27.550 --> 00:27:30.770
thyoroxin reductase and the another

686
00:27:30.790 --> 00:27:32.530
observation they made is

687
00:27:32.550 --> 00:27:35.580
a delayed fiber analysis or elevate due

688
00:27:35.600 --> 00:27:37.740
to the elevation of anti-pharmaceutical

689
00:27:37.760 --> 00:27:40.060
agent or a plasmid activator

690
00:27:40.080 --> 00:27:43.180
inhibitor one so

691
00:27:43.200 --> 00:27:46.220
can an antioxidant therapy

692
00:27:46.240 --> 00:27:49.250
or a promotion of fibronym

693
00:27:49.270 --> 00:27:52.860
fibre analysis can be a

694
00:27:52.880 --> 00:27:55.420
counter measure for methyl isocyanate

695
00:27:55.440 --> 00:27:57.100
exposure

696
00:27:57.120 --> 00:28:00.130
use the graph i am showing here is after

697
00:28:00.150 --> 00:28:02.370
a series of trials with different

698
00:28:02.390 --> 00:28:05.420
anti-accident agents they had some

699
00:28:05.440 --> 00:28:07.010
promising results from

700
00:28:07.030 --> 00:28:11.890
mesnorm which is a

701
00:28:11.910 --> 00:28:15.180
used currently and in adjuvant cancer

702
00:28:15.200 --> 00:28:17.740
therap chemotherapy to protect the

703
00:28:17.760 --> 00:28:19.980
toxicity from the cyclophosphamide

704
00:28:20.000 --> 00:28:23.500
or other chemotherapy agents if by

705
00:28:23.520 --> 00:28:25.820
administering the messner in this methyl

706
00:28:25.840 --> 00:28:27.010
isocyanate

707
00:28:27.030 --> 00:28:30.300
mortality model they could see about 40

708
00:28:30.320 --> 00:28:33.100
percent survival

709
00:28:33.120 --> 00:28:36.770
by 24 hours when they had a combination

710
00:28:36.790 --> 00:28:38.130
therapy of both

711
00:28:38.150 --> 00:28:41.580
mesna and the tpa

712
00:28:41.600 --> 00:28:44.220
it they could improve the survival to

713
00:28:44.240 --> 00:28:44.620
about

714
00:28:44.640 --> 00:28:47.650
65 percent so this is one of the

715
00:28:47.670 --> 00:28:50.700
promising lead candidate that can be

716
00:28:50.720 --> 00:28:53.980
explored further through this program or

717
00:28:54.000 --> 00:28:58.300
eventually through border support

718
00:28:58.320 --> 00:29:01.580
another observation i want to share with

719
00:29:01.600 --> 00:29:02.220
you is

720
00:29:02.240 --> 00:29:05.820
and within the program we support

721
00:29:05.840 --> 00:29:07.980
couple of projects on bromine induced

722
00:29:08.000 --> 00:29:09.890
acute lung injury

723
00:29:09.910 --> 00:29:12.370
um the what i am going sharing here you

724
00:29:12.390 --> 00:29:12.940
with you

725
00:29:12.960 --> 00:29:15.740
is the work from sadie madeline's group

726
00:29:15.760 --> 00:29:17.890
at university of alabama

727
00:29:17.910 --> 00:29:20.530
where they observed that probing on

728
00:29:20.550 --> 00:29:22.370
brominated lipids

729
00:29:22.390 --> 00:29:25.650
can lead cause the degradation

730
00:29:25.670 --> 00:29:28.940
of the high molecular weight hyaluron

731
00:29:28.960 --> 00:29:32.340
and then the degraded small hyaluron are

732
00:29:32.360 --> 00:29:33.500
pro-inflammatory

733
00:29:33.520 --> 00:29:36.370
and they can interf and cause in

734
00:29:36.390 --> 00:29:37.890
pulmonary inflammation

735
00:29:37.910 --> 00:29:41.340
and link injury so is providing

736
00:29:41.360 --> 00:29:44.860
a native or high molecular weight

737
00:29:44.880 --> 00:29:48.130
hyaluron can rescue these animals they

738
00:29:48.150 --> 00:29:48.700
tried

739
00:29:48.720 --> 00:29:51.890
a com with an earbud which is

740
00:29:51.910 --> 00:29:55.250
a hyaluronan solution available for a

741
00:29:55.270 --> 00:29:56.370
nebulization

742
00:29:56.390 --> 00:29:59.500
marketed in europe and using the airboat

743
00:29:59.520 --> 00:30:01.180
they could demonstrate

744
00:30:01.200 --> 00:30:04.060
that it can thereby can reduce the

745
00:30:04.080 --> 00:30:04.700
bromine

746
00:30:04.720 --> 00:30:06.820
induced hyper airway hyper

747
00:30:06.840 --> 00:30:08.460
responsiveness

748
00:30:08.480 --> 00:30:11.250
pulmonary inflammation and also could

749
00:30:11.270 --> 00:30:12.940
they absorb about

750
00:30:12.960 --> 00:30:15.980
45 percent survival in the bromine

751
00:30:16.000 --> 00:30:19.100
acute um mortality

752
00:30:19.120 --> 00:30:21.980
model so this is another promising lead

753
00:30:22.000 --> 00:30:22.940
candidate

754
00:30:22.960 --> 00:30:25.500
who that will be pursued further by

755
00:30:25.520 --> 00:30:26.220
sadist

756
00:30:26.240 --> 00:30:29.500
group at uab i'm

757
00:30:29.520 --> 00:30:33.420
listing here some other ongoing projects

758
00:30:33.440 --> 00:30:35.100
within the portfolio

759
00:30:35.120 --> 00:30:38.130
for example uh sven

760
00:30:38.150 --> 00:30:40.770
george group a duke who earlier tried

761
00:30:40.790 --> 00:30:42.860
with the trap for inhibitor

762
00:30:42.880 --> 00:30:46.620
are now exploring the third generation

763
00:30:46.640 --> 00:30:50.770
trap a1 inhibitor as a counter measure

764
00:30:50.790 --> 00:30:54.060
for a chlorine induced acute lung injury

765
00:30:54.080 --> 00:30:54.700
or drunk

766
00:30:54.720 --> 00:30:58.370
bo or bronchiolitis obliterans in the

767
00:30:58.390 --> 00:31:01.890
mouse and a big modern another center

768
00:31:01.910 --> 00:31:04.460
that is supported through the nih's

769
00:31:04.480 --> 00:31:05.100
program

770
00:31:05.120 --> 00:31:08.860
is the one focused on arsenicals led by

771
00:31:08.880 --> 00:31:12.130
of the atar ahmed at university of

772
00:31:12.150 --> 00:31:13.420
alabama

773
00:31:13.440 --> 00:31:15.740
where they are looking at the skin lung

774
00:31:15.760 --> 00:31:18.460
and kidney toxicity

775
00:31:18.480 --> 00:31:21.980
is the how the arsenicals are modulated

776
00:31:22.000 --> 00:31:24.860
causing the toxicity through epigenetic

777
00:31:24.880 --> 00:31:26.130
modulation

778
00:31:26.150 --> 00:31:28.770
that leads to information tissue damage

779
00:31:28.790 --> 00:31:29.180
and

780
00:31:29.200 --> 00:31:32.700
transcriptional regulation the project

781
00:31:32.720 --> 00:31:35.420
in this is also looking both at acute

782
00:31:35.440 --> 00:31:37.180
and delayed lung injury

783
00:31:37.200 --> 00:31:40.620
from skin exposure to arsenicals and

784
00:31:40.640 --> 00:31:42.940
drivers small molecule inhibitors of

785
00:31:42.960 --> 00:31:44.770
bromo domain signaling

786
00:31:44.790 --> 00:31:48.060
are being explored in this program

787
00:31:48.080 --> 00:31:51.100
um another one i want to touch upon

788
00:31:51.120 --> 00:31:54.940
is how the delayed effects of the

789
00:31:54.960 --> 00:31:57.650
exposure to hydrochloric acid as a model

790
00:31:57.670 --> 00:31:59.340
for chlorine exposure

791
00:31:59.360 --> 00:32:02.060
being pursued by john katrawa such world

792
00:32:02.080 --> 00:32:03.890
dominion university

793
00:32:03.910 --> 00:32:07.010
where he is exploring the heat shock

794
00:32:07.030 --> 00:32:08.620
protein inhibitor

795
00:32:08.640 --> 00:32:11.420
which is currently in trials as an

796
00:32:11.440 --> 00:32:12.860
anti-cancer agent

797
00:32:12.880 --> 00:32:16.370
whether that will rescue the heat shock

798
00:32:16.390 --> 00:32:19.820
19 mediated other

799
00:32:19.840 --> 00:32:25.890
signals for fibronectic signals

800
00:32:25.910 --> 00:32:28.940
so from the so far what i shared with

801
00:32:28.960 --> 00:32:30.460
you you can easily guess

802
00:32:30.480 --> 00:32:32.700
that there are very limited number of

803
00:32:32.720 --> 00:32:34.220
chemicals being

804
00:32:34.240 --> 00:32:37.980
investigated currently in this program

805
00:32:38.000 --> 00:32:40.940
and also the funding opportunities

806
00:32:40.960 --> 00:32:42.300
currently available

807
00:32:42.320 --> 00:32:45.740
are more targeted towards translation to

808
00:32:45.760 --> 00:32:49.420
border i mean more looking at the target

809
00:32:49.440 --> 00:32:51.980
identification of a target and

810
00:32:52.000 --> 00:32:53.820
optimization of the target as a

811
00:32:53.840 --> 00:32:56.940
potential

812
00:32:56.960 --> 00:32:59.740
so the these programs also have other

813
00:32:59.760 --> 00:33:01.740
restrictions because

814
00:33:01.760 --> 00:33:04.530
most of them are um cooperative

815
00:33:04.550 --> 00:33:06.370
agreement mechanisms so

816
00:33:06.390 --> 00:33:09.250
these eu ones are milestone driven and

817
00:33:09.270 --> 00:33:11.010
there's a limited opportunity

818
00:33:11.030 --> 00:33:14.220
for discovery research

819
00:33:14.240 --> 00:33:18.130
and as i mentioned in current portfolio

820
00:33:18.150 --> 00:33:20.530
has only limited number of chemicals

821
00:33:20.550 --> 00:33:22.700
explored and majority of them are known

822
00:33:22.720 --> 00:33:23.100
for

823
00:33:23.120 --> 00:33:25.890
chemical warfare agents as i showed

824
00:33:25.910 --> 00:33:28.370
earlier there are about 200 chemicals

825
00:33:28.390 --> 00:33:29.650
identified by

826
00:33:29.670 --> 00:33:32.060
the chemical threats risk assessment

827
00:33:32.080 --> 00:33:32.860
program at

828
00:33:32.880 --> 00:33:35.420
department of homeland security that

829
00:33:35.440 --> 00:33:36.060
includes

830
00:33:36.080 --> 00:33:38.620
industrial and agricultural chemicals

831
00:33:38.640 --> 00:33:40.370
these chemicals are produced and

832
00:33:40.390 --> 00:33:42.370
transported across the country so there

833
00:33:42.390 --> 00:33:44.460
is a potential for any accidental

834
00:33:44.480 --> 00:33:46.130
exposures like what happened with

835
00:33:46.150 --> 00:33:47.490
chlorine

836
00:33:47.510 --> 00:33:52.060
and there are about 50 of these known

837
00:33:52.080 --> 00:33:54.620
these among the 1 200 chemicals are

838
00:33:54.640 --> 00:33:55.490
pulmonary

839
00:33:55.510 --> 00:33:58.620
and ocular toxicants and majority of

840
00:33:58.640 --> 00:33:59.250
them

841
00:33:59.270 --> 00:34:01.890
understudy what we know is about the

842
00:34:01.910 --> 00:34:04.300
ld50 or lc50

843
00:34:04.320 --> 00:34:06.860
and we have limited understanding on the

844
00:34:06.880 --> 00:34:11.090
pathophysiology of these chemicals

845
00:34:11.110 --> 00:34:13.740
for example i listed here sorry for this

846
00:34:13.760 --> 00:34:14.780
busy slide

847
00:34:14.800 --> 00:34:17.740
the only reason i wanted to show here is

848
00:34:17.760 --> 00:34:19.650
that these are all the chemicals

849
00:34:19.670 --> 00:34:22.610
that are in the citroen that we don't

850
00:34:22.630 --> 00:34:24.050
have much information

851
00:34:24.070 --> 00:34:26.540
about their pathogens of physiological

852
00:34:26.560 --> 00:34:27.650
mechanisms

853
00:34:27.670 --> 00:34:30.850
for examples ammonia is produced in as

854
00:34:30.870 --> 00:34:34.460
fertilizers or a cleaning agent on

855
00:34:34.480 --> 00:34:37.740
boron trichloride is produced

856
00:34:37.760 --> 00:34:40.220
in used in pharmaceuticals and in

857
00:34:40.240 --> 00:34:41.420
electrical work

858
00:34:41.440 --> 00:34:45.260
carbo fueron for example is a

859
00:34:45.280 --> 00:34:47.650
multi-use pesticide and agrochemical

860
00:34:47.670 --> 00:34:49.090
ethylene dioxide

861
00:34:49.110 --> 00:34:51.650
italian oxide you know as an insecticide

862
00:34:51.670 --> 00:34:53.090
as a sterling

863
00:34:53.110 --> 00:34:55.980
sterilizing agent and phosphorous strike

864
00:34:56.000 --> 00:34:57.260
chloride is

865
00:34:57.280 --> 00:34:59.500
used as a chemical warfare agents also

866
00:34:59.520 --> 00:35:00.860
but as a pesticide

867
00:35:00.880 --> 00:35:03.900
and used in the production of plastics

868
00:35:03.920 --> 00:35:07.020
so what we know about these chemicals

869
00:35:07.040 --> 00:35:12.940
is very limited on

870
00:35:12.960 --> 00:35:15.980
excuse me

871
00:35:16.000 --> 00:35:17.810
understanding and getting fundamental

872
00:35:17.830 --> 00:35:20.220
mechanisms of injury for these chemicals

873
00:35:20.240 --> 00:35:24.090
is critical if you want to have any

874
00:35:24.110 --> 00:35:27.740
identification of a target to rescue

875
00:35:27.760 --> 00:35:31.180
on exposure to these chemicals

876
00:35:31.200 --> 00:35:35.020
so any research on the mcm development

877
00:35:35.040 --> 00:35:38.380
for these toxicants in the citra

878
00:35:38.400 --> 00:35:41.900
is difficult at this stage

879
00:35:41.920 --> 00:35:45.260
so what we want to do is in this new

880
00:35:45.280 --> 00:35:47.090
funding opportunity mechanism

881
00:35:47.110 --> 00:35:49.460
to support a development of

882
00:35:49.480 --> 00:35:51.090
pathophysiological

883
00:35:51.110 --> 00:35:53.810
knowledge base for these understudied

884
00:35:53.830 --> 00:35:56.300
chemicals within the center

885
00:35:56.320 --> 00:35:58.540
to support fundamental molecular

886
00:35:58.560 --> 00:35:59.810
cellular

887
00:35:59.830 --> 00:36:01.740
and physiological pathways involved in

888
00:36:01.760 --> 00:36:02.940
acute toxicity

889
00:36:02.960 --> 00:36:05.330
of these chemicals proof of principle

890
00:36:05.350 --> 00:36:07.660
efforts using combination of in vitro

891
00:36:07.680 --> 00:36:09.500
and in vivo models

892
00:36:09.520 --> 00:36:11.330
and support high throughput screening

893
00:36:11.350 --> 00:36:13.500
approaches to identify common mechanisms

894
00:36:13.520 --> 00:36:13.740
of

895
00:36:13.760 --> 00:36:17.020
injury that may lead to some potential

896
00:36:17.040 --> 00:36:20.050
shared therapeutic targets and systemic

897
00:36:20.070 --> 00:36:22.380
toxic effects on inhalational exposure

898
00:36:22.400 --> 00:36:24.860
for example how the delayed and

899
00:36:24.880 --> 00:36:27.570
acute and delayed effects in other

900
00:36:27.590 --> 00:36:29.020
organs

901
00:36:29.040 --> 00:36:31.180
role of susceptibility and co-morbidity

902
00:36:31.200 --> 00:36:32.300
factors

903
00:36:32.320 --> 00:36:34.460
and identification of biomarkers of

904
00:36:34.480 --> 00:36:35.570
exposure

905
00:36:35.590 --> 00:36:38.860
so what we hope

906
00:36:38.880 --> 00:36:41.980
is that this kind of an

907
00:36:42.000 --> 00:36:44.620
investigation into gaining understanding

908
00:36:44.640 --> 00:36:45.330
on the

909
00:36:45.350 --> 00:36:47.980
fundamental mechanisms will serve as a

910
00:36:48.000 --> 00:36:49.980
launch pad towards identification of

911
00:36:50.000 --> 00:36:50.860
targets

912
00:36:50.880 --> 00:36:53.500
for example as i showed earlier the

913
00:36:53.520 --> 00:36:55.740
current programs are all more targeted

914
00:36:55.760 --> 00:36:59.900
on identification of a target

915
00:36:59.920 --> 00:37:03.020
for a confirmation so this will come up

916
00:37:03.040 --> 00:37:03.500
front

917
00:37:03.520 --> 00:37:07.090
as a fundamental research feed into the

918
00:37:07.110 --> 00:37:09.980
existing programs so by gaining

919
00:37:10.000 --> 00:37:11.740
fundamental understanding through this

920
00:37:11.760 --> 00:37:12.860
mechanism

921
00:37:12.880 --> 00:37:15.570
you may the investigators maybe position

922
00:37:15.590 --> 00:37:16.700
themselves

923
00:37:16.720 --> 00:37:19.900
to target and

924
00:37:19.920 --> 00:37:22.300
particular mechanism or particular

925
00:37:22.320 --> 00:37:23.090
candidate

926
00:37:23.110 --> 00:37:26.460
gene as a target for a therapeutic

927
00:37:26.480 --> 00:37:29.420
approach as a counter measure here and

928
00:37:29.440 --> 00:37:31.420
then later through advanced development

929
00:37:31.440 --> 00:37:35.330
by border

930
00:37:35.350 --> 00:37:37.570
and i want to share with you the la

931
00:37:37.590 --> 00:37:39.420
couple of the last couple of slides

932
00:37:39.440 --> 00:37:40.380
about the

933
00:37:40.400 --> 00:37:43.500
uh upcoming meetings and so they are

934
00:37:43.520 --> 00:37:45.020
assessing the current

935
00:37:45.040 --> 00:37:47.330
state of the research on acute lung

936
00:37:47.350 --> 00:37:48.050
injury

937
00:37:48.070 --> 00:37:52.380
and ards irrespective of the origin

938
00:37:52.400 --> 00:37:55.740
and i we can identify common mechanisms

939
00:37:55.760 --> 00:37:57.660
across these

940
00:37:57.680 --> 00:38:00.460
and those mechanisms and the already

941
00:38:00.480 --> 00:38:01.500
existing

942
00:38:01.520 --> 00:38:05.660
approaches to treat those aila and ards

943
00:38:05.680 --> 00:38:08.380
may be useful for the chemical induced

944
00:38:08.400 --> 00:38:09.500
lung injury

945
00:38:09.520 --> 00:38:12.700
so this will open an opportunity for in

946
00:38:12.720 --> 00:38:14.380
interacting with the critical care

947
00:38:14.400 --> 00:38:15.810
physicians on

948
00:38:15.830 --> 00:38:19.740
the toxicologists who are pursuing

949
00:38:19.760 --> 00:38:22.050
pulmonary toxicity mechanisms for

950
00:38:22.070 --> 00:38:24.940
mechanisms for acute lung injury

951
00:38:24.960 --> 00:38:27.980
and we have we are look

952
00:38:28.000 --> 00:38:30.540
excited to host these meetings hopefully

953
00:38:30.560 --> 00:38:31.740
covet permitting

954
00:38:31.760 --> 00:38:34.300
in october at the roadville auditorium

955
00:38:34.320 --> 00:38:35.180
and

956
00:38:35.200 --> 00:38:38.620
i hope many of you join in this meeting

957
00:38:38.640 --> 00:38:40.860
on another aspect of the contract

958
00:38:40.880 --> 00:38:42.380
program is we

959
00:38:42.400 --> 00:38:45.660
host an annual meeting every year and

960
00:38:45.680 --> 00:38:47.420
this year's annual meeting will be

961
00:38:47.440 --> 00:38:48.940
hosted by

962
00:38:48.960 --> 00:38:51.900
atops group at uab and the meeting will

963
00:38:51.920 --> 00:38:53.810
be held on in the month of december

964
00:38:53.830 --> 00:38:54.620
hopefully

965
00:38:54.640 --> 00:38:58.140
kobe permitting at new orleans and

966
00:38:58.160 --> 00:39:00.860
the grant is funded through this new

967
00:39:00.880 --> 00:39:03.260
funding opportunity will also be

968
00:39:03.280 --> 00:39:05.500
participating in the future annual

969
00:39:05.520 --> 00:39:07.500
meetings to share their

970
00:39:07.520 --> 00:39:12.220
research i'll stop there

971
00:39:12.240 --> 00:39:16.050
here now and terry kavanagh and trevor

972
00:39:16.070 --> 00:39:17.420
penning are

973
00:39:17.440 --> 00:39:20.050
the reviewers for the concept lead the

974
00:39:20.070 --> 00:39:20.860
discussion

975
00:39:20.880 --> 00:39:22.720
and thank you for your attention

976
00:39:22.740 --> 00:39:24.140
[Music]

977
00:39:24.160 --> 00:39:27.260
thank you sheree um terry or trevor

978
00:39:27.280 --> 00:39:27.980
whichever you

979
00:39:28.000 --> 00:39:30.220
would like to go first yeah this is

980
00:39:30.240 --> 00:39:31.660
trevor i'm gonna be going

981
00:39:31.680 --> 00:39:34.860
first um i think there was a decision

982
00:39:34.880 --> 00:39:35.330
between

983
00:39:35.350 --> 00:39:37.260
terry and i that i would go first

984
00:39:37.280 --> 00:39:38.460
because uh

985
00:39:38.480 --> 00:39:41.260
i'm most familiar with the uh counteract

986
00:39:41.280 --> 00:39:42.460
program

987
00:39:42.480 --> 00:39:44.300
i have been on the external advisory

988
00:39:44.320 --> 00:39:46.860
board of the u-54 center at rutgers

989
00:39:46.880 --> 00:39:48.380
whose focus has been on

990
00:39:48.400 --> 00:39:52.380
sulfur mustard and i thank srifa he's a

991
00:39:52.400 --> 00:39:55.900
nice presentation because i think he's

992
00:39:55.920 --> 00:39:56.860
identified

993
00:39:56.880 --> 00:40:00.380
some gaps that need attention it's very

994
00:40:00.400 --> 00:40:03.810
it's very clear that uh from the u-54

995
00:40:03.830 --> 00:40:04.940
program

996
00:40:04.960 --> 00:40:06.290
that there are only a number of these

997
00:40:06.310 --> 00:40:08.220
centers of excellence and

998
00:40:08.240 --> 00:40:11.180
uh they're focused on single agents and

999
00:40:11.200 --> 00:40:12.290
although they're doing

1000
00:40:12.310 --> 00:40:15.660
great work in terms of understanding

1001
00:40:15.680 --> 00:40:16.460
mechanism

1002
00:40:16.480 --> 00:40:19.500
identifying of of molecular targets

1003
00:40:19.520 --> 00:40:23.570
and also identifying agents that

1004
00:40:23.590 --> 00:40:27.090
can be used as counter measures

1005
00:40:27.110 --> 00:40:29.500
they can't do it all and i think that

1006
00:40:29.520 --> 00:40:31.020
the program that sri

1007
00:40:31.040 --> 00:40:34.140
is presenting provides an opportunity to

1008
00:40:34.160 --> 00:40:35.420
do a lot more

1009
00:40:35.440 --> 00:40:39.180
on a broader range of agents

1010
00:40:39.200 --> 00:40:41.810
the things i that do come to mind that

1011
00:40:41.830 --> 00:40:42.380
perhaps

1012
00:40:42.400 --> 00:40:46.780
need some attention are as follows

1013
00:40:46.800 --> 00:40:50.050
sri identified 200 chemicals

1014
00:40:50.070 --> 00:40:52.050
that have been identified by the

1015
00:40:52.070 --> 00:40:53.090
chemical

1016
00:40:53.110 --> 00:40:56.290
terrorism risk assessment and i'd like

1017
00:40:56.310 --> 00:40:56.780
to know

1018
00:40:56.800 --> 00:40:58.540
more about how they did that risk

1019
00:40:58.560 --> 00:41:00.540
assessment to come up with those 200

1020
00:41:00.560 --> 00:41:01.570
chemicals

1021
00:41:01.590 --> 00:41:04.460
but assuming they've done it right they

1022
00:41:04.480 --> 00:41:06.860
then come up with 50 chemicals

1023
00:41:06.880 --> 00:41:09.980
that sri identified as being

1024
00:41:10.000 --> 00:41:13.900
of potential uh pulmonary threats

1025
00:41:13.920 --> 00:41:18.540
and uh as you saw in his presentation

1026
00:41:18.560 --> 00:41:20.700
uh we know very little about many of

1027
00:41:20.720 --> 00:41:23.810
these chemicals uh he indicated that so

1028
00:41:23.830 --> 00:41:27.660
we have the ld50s but not much else and

1029
00:41:27.680 --> 00:41:29.260
i think one thing

1030
00:41:29.280 --> 00:41:32.290
that actually may not be a component of

1031
00:41:32.310 --> 00:41:34.220
what he proposes but does

1032
00:41:34.240 --> 00:41:36.460
bring to mind and that is what is the

1033
00:41:36.480 --> 00:41:38.460
margin of exposure what's the margin of

1034
00:41:38.480 --> 00:41:40.220
safety here do we know

1035
00:41:40.240 --> 00:41:42.290
the knowers and the lowest from animal

1036
00:41:42.310 --> 00:41:44.860
studies that we can extrapolate

1037
00:41:44.880 --> 00:41:46.780
safe human exposures i think that's an

1038
00:41:46.800 --> 00:41:48.860
important component to consider

1039
00:41:48.880 --> 00:41:51.330
if we are going to have the protective

1040
00:41:51.350 --> 00:41:54.140
of human health

1041
00:41:54.160 --> 00:41:56.290
i'd also like to think that if we have

1042
00:41:56.310 --> 00:41:58.380
50 chemicals

1043
00:41:58.400 --> 00:42:00.940
there may have to be some for into price

1044
00:42:00.960 --> 00:42:01.810
rising

1045
00:42:01.830 --> 00:42:04.780
which chemicals we might actually want

1046
00:42:04.800 --> 00:42:05.180
to

1047
00:42:05.200 --> 00:42:08.220
think about investing uh funds into

1048
00:42:08.240 --> 00:42:11.260
uh understanding more about mechanism

1049
00:42:11.280 --> 00:42:13.090
the rfa that would probably come out of

1050
00:42:13.110 --> 00:42:14.940
this ultimately

1051
00:42:14.960 --> 00:42:17.020
would could be of two types it could be

1052
00:42:17.040 --> 00:42:19.020
an rfa where it's just going to take

1053
00:42:19.040 --> 00:42:21.500
the best the best applications or there

1054
00:42:21.520 --> 00:42:24.460
could be some prioritization in the rfa

1055
00:42:24.480 --> 00:42:27.260
of the chemicals of most concern and i

1056
00:42:27.280 --> 00:42:28.540
think that perhaps

1057
00:42:28.560 --> 00:42:31.420
that needs some attention a broader

1058
00:42:31.440 --> 00:42:33.500
aspect of this whole program of course

1059
00:42:33.520 --> 00:42:38.540
is the opportunity to expand it into

1060
00:42:38.560 --> 00:42:41.020
occupational exposures and hazmat

1061
00:42:41.040 --> 00:42:42.620
workers as well as the

1062
00:42:42.640 --> 00:42:46.050
disaster response component of nahs

1063
00:42:46.070 --> 00:42:48.940
as well which spoke to the accidents i

1064
00:42:48.960 --> 00:42:52.380
think that sri was referring to

1065
00:42:52.400 --> 00:42:56.540
so knowing that there are 50 chemicals

1066
00:42:56.560 --> 00:42:59.980
at least that we want to uh focus on

1067
00:43:00.000 --> 00:43:01.980
one has to wonder whether 12 million

1068
00:43:02.000 --> 00:43:04.380
dollars is going to do the job

1069
00:43:04.400 --> 00:43:06.540
and so you know this could be a tiered

1070
00:43:06.560 --> 00:43:09.260
program whereby we start off small

1071
00:43:09.280 --> 00:43:12.380
and then actually develop a increased

1072
00:43:12.400 --> 00:43:13.980
funding stream for it

1073
00:43:14.000 --> 00:43:17.420
based on metrics of success

1074
00:43:17.440 --> 00:43:20.290
and that brings me to what the metrics

1075
00:43:20.310 --> 00:43:22.290
of success are going to be

1076
00:43:22.310 --> 00:43:24.220
and i think this has to be spelled out

1077
00:43:24.240 --> 00:43:25.330
in the rfa

1078
00:43:25.350 --> 00:43:28.780
that might go with this and uh i think

1079
00:43:28.800 --> 00:43:30.290
i think they're self-evident but i think

1080
00:43:30.310 --> 00:43:31.900
they need to be emphasized

1081
00:43:31.920 --> 00:43:34.940
and clearly they would be identification

1082
00:43:34.960 --> 00:43:36.940
of a new mode of action for

1083
00:43:36.960 --> 00:43:40.420
a toxicon in terms of this pulmonary

1084
00:43:40.440 --> 00:43:43.420
pathophysiology uh wherever or not

1085
00:43:43.440 --> 00:43:46.290
a a lead compound has been identified or

1086
00:43:46.310 --> 00:43:48.220
whether we can repurpose an existing

1087
00:43:48.240 --> 00:43:49.090
drug

1088
00:43:49.110 --> 00:43:52.460
to uh tackle that target and

1089
00:43:52.480 --> 00:43:54.460
and whether or not something is ready

1090
00:43:54.480 --> 00:43:56.380
for transition either to the eu

1091
00:43:56.400 --> 00:43:58.140
mechanism or to barda

1092
00:43:58.160 --> 00:44:00.700
i think those are things that should be

1093
00:44:00.720 --> 00:44:01.330
uh

1094
00:44:01.350 --> 00:44:03.980
should be considered uh as we move

1095
00:44:04.000 --> 00:44:05.500
forward

1096
00:44:05.520 --> 00:44:08.380
i like the concept also that he raised

1097
00:44:08.400 --> 00:44:08.780
that

1098
00:44:08.800 --> 00:44:11.020
many of these agents might have a common

1099
00:44:11.040 --> 00:44:13.180
mechanism of action meaning that we

1100
00:44:13.200 --> 00:44:15.090
might be able to have

1101
00:44:15.110 --> 00:44:17.330
a counter measure that might actually

1102
00:44:17.350 --> 00:44:20.620
deal with pulmonary pathophysiology

1103
00:44:20.640 --> 00:44:22.620
that might be applicable to more than

1104
00:44:22.640 --> 00:44:25.500
one uh toxicant exposure

1105
00:44:25.520 --> 00:44:27.570
but overall i'm supportive of this

1106
00:44:27.590 --> 00:44:29.740
concept i i just wonder

1107
00:44:29.760 --> 00:44:31.260
whether or not some effort has to be put

1108
00:44:31.280 --> 00:44:33.090
into prioritizing chemicals

1109
00:44:33.110 --> 00:44:35.180
and how much money we wish to invest in

1110
00:44:35.200 --> 00:44:36.220
this program

1111
00:44:36.240 --> 00:44:41.420
very important topic

1112
00:44:41.440 --> 00:44:42.700
shari did you want to respond to those

1113
00:44:42.720 --> 00:44:43.660
questions or do you wanna hear from

1114
00:44:43.680 --> 00:44:44.700
terry nixon

1115
00:44:44.720 --> 00:44:47.500
um and i had earlier discussions with

1116
00:44:47.520 --> 00:44:48.050
both

1117
00:44:48.070 --> 00:44:50.290
teddy and trevor on that i took some of

1118
00:44:50.310 --> 00:44:52.220
the points and then

1119
00:44:52.240 --> 00:44:55.420
definitely the

1120
00:44:55.440 --> 00:44:57.810
i mentioned to both terry and trevor at

1121
00:44:57.830 --> 00:44:58.860
the time

1122
00:44:58.880 --> 00:45:01.330
uh it's unfortunate i cannot share what

1123
00:45:01.350 --> 00:45:03.330
are the chemicals in the list i

1124
00:45:03.350 --> 00:45:06.290
used some here as an example but the

1125
00:45:06.310 --> 00:45:07.900
investigators who are invest

1126
00:45:07.920 --> 00:45:10.940
interested may have to contact us so

1127
00:45:10.960 --> 00:45:13.180
whether the chemicals they would like to

1128
00:45:13.200 --> 00:45:14.220
explore is

1129
00:45:14.240 --> 00:45:17.020
a part of the citron and we can provide

1130
00:45:17.040 --> 00:45:18.290
that information

1131
00:45:18.310 --> 00:45:22.050
and as um trevor mentioned our goal is

1132
00:45:22.070 --> 00:45:24.700
um when we write the rfa we are going to

1133
00:45:24.720 --> 00:45:27.020
make all those points very clear

1134
00:45:27.040 --> 00:45:30.140
the um if a center

1135
00:45:30.160 --> 00:45:32.940
if a grantee is interested in high

1136
00:45:32.960 --> 00:45:34.780
throughput screening for three or four

1137
00:45:34.800 --> 00:45:35.180
bank

1138
00:45:35.200 --> 00:45:37.020
chemicals that may lead to

1139
00:45:37.040 --> 00:45:39.090
identification of a common mechanism

1140
00:45:39.110 --> 00:45:41.180
or common mode of action or common

1141
00:45:41.200 --> 00:45:42.620
target for a

1142
00:45:42.640 --> 00:45:45.810
counter measure development so um all

1143
00:45:45.830 --> 00:45:46.460
those

1144
00:45:46.480 --> 00:45:48.460
um are very nice points we will

1145
00:45:48.480 --> 00:45:49.660
definitely consider

1146
00:45:49.680 --> 00:45:55.660
in that while we're writing the rfa

1147
00:45:55.680 --> 00:45:58.940
okay hi terry you wanna sure uh so

1148
00:45:58.960 --> 00:46:01.330
um i i fully agree with the sentiments

1149
00:46:01.350 --> 00:46:02.620
of trevor and

1150
00:46:02.640 --> 00:46:06.940
and uh uh agree with uh the

1151
00:46:06.960 --> 00:46:09.500
answers that that sri has given as being

1152
00:46:09.520 --> 00:46:11.810
uh important uh responses

1153
00:46:11.830 --> 00:46:13.180
one of the things that i thought would

1154
00:46:13.200 --> 00:46:15.260
also be important to highlight

1155
00:46:15.280 --> 00:46:18.460
in the rfa would be chemical

1156
00:46:18.480 --> 00:46:20.700
in silicon modeling if there's a common

1157
00:46:20.720 --> 00:46:22.700
mechanism for instance that's identified

1158
00:46:22.720 --> 00:46:23.660
across

1159
00:46:23.680 --> 00:46:27.810
multiple agents then perhaps

1160
00:46:27.830 --> 00:46:32.050
in the rfa that that the um

1161
00:46:32.070 --> 00:46:34.540
that the institute's open to uh that

1162
00:46:34.560 --> 00:46:35.570
kind of approach

1163
00:46:35.590 --> 00:46:37.570
uh because i think those kinds of things

1164
00:46:37.590 --> 00:46:39.330
can also help to accelerate

1165
00:46:39.350 --> 00:46:41.660
discovery uh of course you're going to

1166
00:46:41.680 --> 00:46:44.050
need both in vitro and vipo

1167
00:46:44.070 --> 00:46:46.460
verification but still i think that the

1168
00:46:46.480 --> 00:46:47.740
in silico modeling

1169
00:46:47.760 --> 00:46:49.500
has come a long way and that can that

1170
00:46:49.520 --> 00:46:50.780
can add to this

1171
00:46:50.800 --> 00:46:52.140
the other thing we identified as

1172
00:46:52.160 --> 00:46:55.980
potential issue here has to do with

1173
00:46:56.000 --> 00:46:58.700
engaging pharmaceutical firms as

1174
00:46:58.720 --> 00:47:00.700
partners in some of the research

1175
00:47:00.720 --> 00:47:03.020
and perceived markets and all of those

1176
00:47:03.040 --> 00:47:03.980
issues

1177
00:47:04.000 --> 00:47:06.620
the idea that a lot of this would be

1178
00:47:06.640 --> 00:47:09.180
especially subcontracting for

1179
00:47:09.200 --> 00:47:10.860
for some of the more expensive aspects

1180
00:47:10.880 --> 00:47:12.940
of the research

1181
00:47:12.960 --> 00:47:14.780
would would i think allay some of those

1182
00:47:14.800 --> 00:47:16.540
fears but still this is a

1183
00:47:16.560 --> 00:47:18.050
has been as my understanding is a little

1184
00:47:18.070 --> 00:47:19.740
bit of an issue um

1185
00:47:19.760 --> 00:47:21.980
to engage pharmaceutical partners

1186
00:47:22.000 --> 00:47:24.700
especially repurposing some of their

1187
00:47:24.720 --> 00:47:26.620
existing pharmaceuticals so they also

1188
00:47:26.640 --> 00:47:28.780
have a lot of the industry has a lot of

1189
00:47:28.800 --> 00:47:29.570
things that

1190
00:47:29.590 --> 00:47:32.460
you know they've not um taken all the

1191
00:47:32.480 --> 00:47:34.290
way through phase three clinical trials

1192
00:47:34.310 --> 00:47:35.330
but still might have

1193
00:47:35.350 --> 00:47:37.330
um and may have failed in those droughts

1194
00:47:37.350 --> 00:47:38.380
but still may have

1195
00:47:38.400 --> 00:47:41.180
a lot of application in emergency

1196
00:47:41.200 --> 00:47:42.700
situations that could be

1197
00:47:42.720 --> 00:47:46.780
uh could be pursued i agree that the

1198
00:47:46.800 --> 00:47:49.980
uh prioritization is a is a huge issue

1199
00:47:50.000 --> 00:47:51.740
and so obviously it's going to be

1200
00:47:51.760 --> 00:47:54.530
important in the rfa that

1201
00:47:54.550 --> 00:47:56.220
that applicants are encouraged to

1202
00:47:56.240 --> 00:47:58.780
contact a program officer to determine

1203
00:47:58.800 --> 00:47:59.900
whether or not

1204
00:47:59.920 --> 00:48:03.980
what they're interested in uh is is

1205
00:48:04.000 --> 00:48:07.660
likely to be impactful

1206
00:48:07.680 --> 00:48:11.020
one thing also we talked about that is a

1207
00:48:11.040 --> 00:48:13.660
is potentially an impediment for

1208
00:48:13.680 --> 00:48:14.530
investigators

1209
00:48:14.550 --> 00:48:16.050
is the idea that some of these things

1210
00:48:16.070 --> 00:48:18.050
are likely to be

1211
00:48:18.070 --> 00:48:20.220
to require a security clearance do you

1212
00:48:20.240 --> 00:48:21.660
work on them

1213
00:48:21.680 --> 00:48:24.460
and we um you know again wonder how

1214
00:48:24.480 --> 00:48:26.290
that's going to be handled in an rfa

1215
00:48:26.310 --> 00:48:29.980
uh because there could be issues for

1216
00:48:30.000 --> 00:48:31.570
certain groups to be able to apply for

1217
00:48:31.590 --> 00:48:33.180
the work if in fact

1218
00:48:33.200 --> 00:48:35.980
they can't get a security clearance and

1219
00:48:36.000 --> 00:48:37.740
there's obviously bureaucratic

1220
00:48:37.760 --> 00:48:39.660
hurdles and hassles associated with that

1221
00:48:39.680 --> 00:48:41.260
finally

1222
00:48:41.280 --> 00:48:43.420
extremely important is that the rfa

1223
00:48:43.440 --> 00:48:44.940
include information

1224
00:48:44.960 --> 00:48:47.090
on chemical safety plans for

1225
00:48:47.110 --> 00:48:48.530
laboratories that are working with these

1226
00:48:48.550 --> 00:48:49.500
agents

1227
00:48:49.520 --> 00:48:52.530
and especially in the context of their

1228
00:48:52.550 --> 00:48:53.900
university regulations

1229
00:48:53.920 --> 00:48:56.290
and any federal regulations that come

1230
00:48:56.310 --> 00:48:57.500
from working with

1231
00:48:57.520 --> 00:49:02.220
select agents

1232
00:49:02.240 --> 00:49:04.700
with regard to that question it depends

1233
00:49:04.720 --> 00:49:05.740
on the how much

1234
00:49:05.760 --> 00:49:08.140
amount of the toxic chemicals you are

1235
00:49:08.160 --> 00:49:09.260
going to

1236
00:49:09.280 --> 00:49:12.460
hold at in your laboratory at a time

1237
00:49:12.480 --> 00:49:16.050
if it is a smaller amounts we don't may

1238
00:49:16.070 --> 00:49:16.940
have to go through

1239
00:49:16.960 --> 00:49:18.700
all the bureaucratic process of getting

1240
00:49:18.720 --> 00:49:20.220
the security clearance

1241
00:49:20.240 --> 00:49:22.460
but again it depends on the amount and

1242
00:49:22.480 --> 00:49:24.620
the type of the compound

1243
00:49:24.640 --> 00:49:27.810
we try to help the grantees to go

1244
00:49:27.830 --> 00:49:29.570
through that process as much as possible

1245
00:49:29.590 --> 00:49:30.700
but it is then

1246
00:49:30.720 --> 00:49:32.620
mostly handled by the academic

1247
00:49:32.640 --> 00:49:35.090
institutions

1248
00:49:35.110 --> 00:49:37.810
so sri this was a concern that terry and

1249
00:49:37.830 --> 00:49:40.050
i did have about the biohazard safety

1250
00:49:40.070 --> 00:49:41.980
because if the

1251
00:49:42.000 --> 00:49:45.980
target is pulmonary pathophysiology or

1252
00:49:46.000 --> 00:49:47.330
pulmonary damage

1253
00:49:47.350 --> 00:49:49.660
then one can imagine that whole animal

1254
00:49:49.680 --> 00:49:51.570
studies this would be an inhalation

1255
00:49:51.590 --> 00:49:55.090
uh paradigm and so i think i think i

1256
00:49:55.110 --> 00:49:56.940
would endorse what terry said and that

1257
00:49:56.960 --> 00:49:58.460
is we do need

1258
00:49:58.480 --> 00:50:01.090
in the rfa some explicit language about

1259
00:50:01.110 --> 00:50:02.460
biohazards

1260
00:50:02.480 --> 00:50:06.140
yeah definitely that will be and also

1261
00:50:06.160 --> 00:50:09.420
um and also um may not

1262
00:50:09.440 --> 00:50:12.530
all the institutions be ready to do

1263
00:50:12.550 --> 00:50:15.090
an expo inhalation or a nose only even a

1264
00:50:15.110 --> 00:50:17.180
nose only explode inhalation exposure of

1265
00:50:17.200 --> 00:50:18.620
these chemicals

1266
00:50:18.640 --> 00:50:21.980
and the

1267
00:50:22.000 --> 00:50:24.940
rfa will be written such a way that if

1268
00:50:24.960 --> 00:50:26.460
there are any

1269
00:50:26.480 --> 00:50:29.420
investigator initiated but maybe would

1270
00:50:29.440 --> 00:50:31.810
like to use a contract facility

1271
00:50:31.830 --> 00:50:34.460
to support that kind of an animal

1272
00:50:34.480 --> 00:50:36.380
exposure studies but they can do

1273
00:50:36.400 --> 00:50:38.810
other mechanistic studies on the in the

1274
00:50:38.830 --> 00:50:41.330
laboratory we may have to

1275
00:50:41.350 --> 00:50:46.290
include that also as part of the rfa

1276
00:50:46.310 --> 00:50:48.050
one other thing i had in my notes which

1277
00:50:48.070 --> 00:50:49.420
i forgot to mention

1278
00:50:49.440 --> 00:50:52.620
was the issue of acute toxicity

1279
00:50:52.640 --> 00:50:55.810
versus delayed lung injury uh

1280
00:50:55.830 --> 00:50:59.260
you know fibrosis for example can be a

1281
00:50:59.280 --> 00:51:02.860
a very uh delayed response to a toxicant

1282
00:51:02.880 --> 00:51:04.700
exposure so i think

1283
00:51:04.720 --> 00:51:07.180
we want to indicate in the rfa that

1284
00:51:07.200 --> 00:51:08.620
we're interested not only

1285
00:51:08.640 --> 00:51:11.090
in acute toxicity but delayed injury as

1286
00:51:11.110 --> 00:51:12.940
well

1287
00:51:12.960 --> 00:51:16.860
yeah definitely we have a few uh

1288
00:51:16.880 --> 00:51:18.290
council members queued up here who want

1289
00:51:18.310 --> 00:51:20.380
to ask some questions i think dr goldman

1290
00:51:20.400 --> 00:51:21.570
i believe you were

1291
00:51:21.590 --> 00:51:24.220
next in line well i wanted to start out

1292
00:51:24.240 --> 00:51:25.500
with just saying wow

1293
00:51:25.520 --> 00:51:27.660
i think this is a really great program

1294
00:51:27.680 --> 00:51:29.570
and it's one of these things that you

1295
00:51:29.590 --> 00:51:30.860
know i just want to go why didn't i

1296
00:51:30.880 --> 00:51:31.660
think of that

1297
00:51:31.680 --> 00:51:33.740
i mean you know that we have for so many

1298
00:51:33.760 --> 00:51:34.700
years not just

1299
00:51:34.720 --> 00:51:36.460
you know seeing these as potential

1300
00:51:36.480 --> 00:51:38.460
homeland security threats

1301
00:51:38.480 --> 00:51:41.090
but also many of these chemicals

1302
00:51:41.110 --> 00:51:41.900
regularly

1303
00:51:41.920 --> 00:51:44.220
exposed workers have exposed communities

1304
00:51:44.240 --> 00:51:45.660
that have releases

1305
00:51:45.680 --> 00:51:48.140
and to not have developed specific

1306
00:51:48.160 --> 00:51:50.290
agents for their treatment and and when

1307
00:51:50.310 --> 00:51:52.050
you look at the progress that's been

1308
00:51:52.070 --> 00:51:53.980
that's being made already i'm just so

1309
00:51:54.000 --> 00:51:55.660
impressed by this program

1310
00:51:55.680 --> 00:51:56.860
so there were a couple of things i just

1311
00:51:56.880 --> 00:51:58.700
wanted to say about that and

1312
00:51:58.720 --> 00:52:02.050
one is that you know to i hope

1313
00:52:02.070 --> 00:52:03.900
you know those of you involved from the

1314
00:52:03.920 --> 00:52:05.180
um nia

1315
00:52:05.200 --> 00:52:08.290
ehs side are making sure that it's very

1316
00:52:08.310 --> 00:52:09.500
clear

1317
00:52:09.520 --> 00:52:11.900
when some of these countermeasures may

1318
00:52:11.920 --> 00:52:14.220
be useful in occupational medicine

1319
00:52:14.240 --> 00:52:17.260
or in pulmonary medicine and

1320
00:52:17.280 --> 00:52:20.220
and could be applicable on many levels

1321
00:52:20.240 --> 00:52:22.460
not just in the case of warfare

1322
00:52:22.480 --> 00:52:24.620
that you know there that the information

1323
00:52:24.640 --> 00:52:26.700
about these countermeasures isn't buried

1324
00:52:26.720 --> 00:52:27.260
you know

1325
00:52:27.280 --> 00:52:29.900
under um you know in classified systems

1326
00:52:29.920 --> 00:52:31.570
that people can't access

1327
00:52:31.590 --> 00:52:33.660
i mean and so you know i just really

1328
00:52:33.680 --> 00:52:34.780
want to urge

1329
00:52:34.800 --> 00:52:36.780
uh to have that information out in the

1330
00:52:36.800 --> 00:52:38.220
open where p

1331
00:52:38.240 --> 00:52:41.020
you know physicians and public health um

1332
00:52:41.040 --> 00:52:41.810
people can

1333
00:52:41.830 --> 00:52:44.460
can access it um anywhere in the world

1334
00:52:44.480 --> 00:52:45.090
you know

1335
00:52:45.110 --> 00:52:47.980
because these releases happen everywhere

1336
00:52:48.000 --> 00:52:48.380
the

1337
00:52:48.400 --> 00:52:51.020
um the other thing i i wanted to say is

1338
00:52:51.040 --> 00:52:51.740
that

1339
00:52:51.760 --> 00:52:55.090
i think you might be able to get actual

1340
00:52:55.110 --> 00:52:57.330
support from the chemical industry

1341
00:52:57.350 --> 00:52:59.660
the people who make these chemicals they

1342
00:52:59.680 --> 00:53:01.660
want to be responsible stewards

1343
00:53:01.680 --> 00:53:05.020
they themselves um have situations where

1344
00:53:05.040 --> 00:53:06.780
they want to be responsive if they have

1345
00:53:06.800 --> 00:53:07.570
a train load

1346
00:53:07.590 --> 00:53:10.050
of one of these things that um that

1347
00:53:10.070 --> 00:53:11.810
spills in a community and people are

1348
00:53:11.830 --> 00:53:12.460
exposed

1349
00:53:12.480 --> 00:53:16.290
and i i would not be at all um

1350
00:53:16.310 --> 00:53:18.860
embarrassed about seeking you know their

1351
00:53:18.880 --> 00:53:20.620
actual financial support unlike

1352
00:53:20.640 --> 00:53:22.220
it's it's a little different than what

1353
00:53:22.240 --> 00:53:23.500
you might go to the pharmaceutical

1354
00:53:23.520 --> 00:53:24.620
industry for but

1355
00:53:24.640 --> 00:53:26.460
i mean they actually could be involved

1356
00:53:26.480 --> 00:53:28.050
in that in doing research in their own

1357
00:53:28.070 --> 00:53:29.180
labs but they

1358
00:53:29.200 --> 00:53:31.020
i could see they're being willing to do

1359
00:53:31.040 --> 00:53:32.940
cooperative research some kind of public

1360
00:53:32.960 --> 00:53:33.740
private

1361
00:53:33.760 --> 00:53:35.500
around some of it just to show that

1362
00:53:35.520 --> 00:53:37.090
they're being responsible

1363
00:53:37.110 --> 00:53:40.530
um in terms of these agents and

1364
00:53:40.550 --> 00:53:43.330
and last but not least i just know of

1365
00:53:43.350 --> 00:53:45.090
course that the occupational medicine

1366
00:53:45.110 --> 00:53:47.180
and pulmonary medicine community will be

1367
00:53:47.200 --> 00:53:48.940
really excited about this and i hope

1368
00:53:48.960 --> 00:53:49.500
that

1369
00:53:49.520 --> 00:53:52.380
the outreach plans for this program will

1370
00:53:52.400 --> 00:53:53.810
include at some point in time

1371
00:53:53.830 --> 00:53:55.500
you know doing sessions at their

1372
00:53:55.520 --> 00:53:56.940
meetings and

1373
00:53:56.960 --> 00:54:00.050
um and and informing them of some of

1374
00:54:00.070 --> 00:54:00.460
this

1375
00:54:00.480 --> 00:54:03.260
it it's just so exciting uh to think

1376
00:54:03.280 --> 00:54:04.780
about the availability these treatments

1377
00:54:04.800 --> 00:54:06.860
obviously i'm all about prevention

1378
00:54:06.880 --> 00:54:09.660
but realistically um these things happen

1379
00:54:09.680 --> 00:54:10.050
and

1380
00:54:10.070 --> 00:54:12.700
it's it's great uh to be um developing

1381
00:54:12.720 --> 00:54:14.140
these counter measures

1382
00:54:14.160 --> 00:54:17.330
thank you thank you i mean we have been

1383
00:54:17.350 --> 00:54:18.860
trying at the

1384
00:54:18.880 --> 00:54:21.020
american thoracic society meeting there

1385
00:54:21.040 --> 00:54:21.900
is um

1386
00:54:21.920 --> 00:54:24.380
within the environmental health of

1387
00:54:24.400 --> 00:54:25.980
occupational health group

1388
00:54:26.000 --> 00:54:28.460
we have a smaller group on a disaster

1389
00:54:28.480 --> 00:54:29.260
management

1390
00:54:29.280 --> 00:54:31.980
and then at all the annual meetings we

1391
00:54:32.000 --> 00:54:33.980
are making our efforts to bring

1392
00:54:34.000 --> 00:54:36.700
the attention of the physicians to this

1393
00:54:36.720 --> 00:54:37.020
pro

1394
00:54:37.040 --> 00:54:38.700
physicians and other scientists to this

1395
00:54:38.720 --> 00:54:40.620
program so there's a whole group of

1396
00:54:40.640 --> 00:54:42.050
people over the years who've been

1397
00:54:42.070 --> 00:54:44.290
involved in developing the eagles

1398
00:54:44.310 --> 00:54:46.380
um you know and they would be very

1399
00:54:46.400 --> 00:54:48.860
interested in this as well

1400
00:54:48.880 --> 00:54:51.570
thank you our next question then is from

1401
00:54:51.590 --> 00:54:51.980
dr

1402
00:54:52.000 --> 00:54:56.700
white newsome hey where

1403
00:54:56.720 --> 00:54:59.900
all right okay just a second oh yeah dr

1404
00:54:59.920 --> 00:55:01.260
sri thank you so much

1405
00:55:01.280 --> 00:55:04.140
um and my question kind of touches on

1406
00:55:04.160 --> 00:55:05.500
our question or comment kind of touches

1407
00:55:05.520 --> 00:55:07.740
on a point that dr penny brought up

1408
00:55:07.760 --> 00:55:10.620
more so about the prioritization of

1409
00:55:10.640 --> 00:55:11.260
agents

1410
00:55:11.280 --> 00:55:13.980
and i just remember working in several

1411
00:55:14.000 --> 00:55:15.500
chemical facilities with

1412
00:55:15.520 --> 00:55:18.140
large amounts of bad stuff particularly

1413
00:55:18.160 --> 00:55:19.500
anhydrous ammonia

1414
00:55:19.520 --> 00:55:22.940
and while that was 15 years ago my hope

1415
00:55:22.960 --> 00:55:23.420
is there

1416
00:55:23.440 --> 00:55:24.860
that there is a more heightened sense of

1417
00:55:24.880 --> 00:55:26.460
responsibility around

1418
00:55:26.480 --> 00:55:28.770
the chemical industry but again i don't

1419
00:55:28.790 --> 00:55:29.980
think that plays out

1420
00:55:30.000 --> 00:55:32.860
all times in all places particularly in

1421
00:55:32.880 --> 00:55:34.770
facilities where they're in low-income

1422
00:55:34.790 --> 00:55:36.700
communities and communities of color

1423
00:55:36.720 --> 00:55:37.980
and so i'm interested in really

1424
00:55:38.000 --> 00:55:40.460
understanding um as you think about this

1425
00:55:40.480 --> 00:55:41.660
rfa

1426
00:55:41.680 --> 00:55:43.980
are there any what are some of the

1427
00:55:44.000 --> 00:55:45.980
criteria of prioritization that you're

1428
00:55:46.000 --> 00:55:46.860
looking at

1429
00:55:46.880 --> 00:55:48.700
uh is it who's living around these

1430
00:55:48.720 --> 00:55:50.620
stockpiles even some of the smaller

1431
00:55:50.640 --> 00:55:51.260
amounts of

1432
00:55:51.280 --> 00:55:53.570
really bad stuff um are there certain

1433
00:55:53.590 --> 00:55:55.740
folks that continue to be more at risk

1434
00:55:55.760 --> 00:55:58.380
and exposed either through occupation or

1435
00:55:58.400 --> 00:55:58.770
again

1436
00:55:58.790 --> 00:56:01.090
just the places that they live and then

1437
00:56:01.110 --> 00:56:02.860
thinking about some of the accidents

1438
00:56:02.880 --> 00:56:04.940
that continue to happen

1439
00:56:04.960 --> 00:56:06.220
particularly in some of these deep

1440
00:56:06.240 --> 00:56:08.140
chemical corridors in houston and

1441
00:56:08.160 --> 00:56:09.330
louisiana

1442
00:56:09.350 --> 00:56:12.050
um you know should this be a part of

1443
00:56:12.070 --> 00:56:14.620
again your criteria of prioritization

1444
00:56:14.640 --> 00:56:17.500
um again i'm not sure you know if this

1445
00:56:17.520 --> 00:56:19.500
type of research of those questions have

1446
00:56:19.520 --> 00:56:19.810
been

1447
00:56:19.830 --> 00:56:21.740
asked um particularly around

1448
00:56:21.760 --> 00:56:23.420
environmental justice and equity and

1449
00:56:23.440 --> 00:56:25.260
who's being exposed but i think if there

1450
00:56:25.280 --> 00:56:26.770
is an opportunity

1451
00:56:26.790 --> 00:56:28.050
um through the work that you're

1452
00:56:28.070 --> 00:56:29.810
proposing to make that a part of the

1453
00:56:29.830 --> 00:56:30.700
criteria

1454
00:56:30.720 --> 00:56:33.330
in some way um that will be super useful

1455
00:56:33.350 --> 00:56:34.700
not only from an environmental justice

1456
00:56:34.720 --> 00:56:37.020
standpoint but an equity standpoint

1457
00:56:37.040 --> 00:56:39.740
uh from prevention as well as in

1458
00:56:39.760 --> 00:56:40.620
response

1459
00:56:40.640 --> 00:56:43.020
so um thanks so much for what you shared

1460
00:56:43.040 --> 00:56:43.660
and

1461
00:56:43.680 --> 00:56:45.740
whatever you can share will be great

1462
00:56:45.760 --> 00:56:47.570
thank you i mean the

1463
00:56:47.590 --> 00:56:50.050
currently the way the program has been

1464
00:56:50.070 --> 00:56:51.090
designed

1465
00:56:51.110 --> 00:56:54.380
is to focus on the therapy promoting the

1466
00:56:54.400 --> 00:56:56.050
development of countermeasures

1467
00:56:56.070 --> 00:56:59.260
so that we are in a more in at least a

1468
00:56:59.280 --> 00:57:01.020
preparedness mode

1469
00:57:01.040 --> 00:57:05.570
and the priority chemicals are

1470
00:57:05.590 --> 00:57:08.530
annually assessed by the in consultation

1471
00:57:08.550 --> 00:57:10.940
with department of homeland security

1472
00:57:10.960 --> 00:57:13.660
and also with border border will come

1473
00:57:13.680 --> 00:57:15.260
with a list of chemicals

1474
00:57:15.280 --> 00:57:17.570
that have been indicated to them as

1475
00:57:17.590 --> 00:57:19.020
priority chemicals

1476
00:57:19.040 --> 00:57:22.290
for which the countermeasures need to be

1477
00:57:22.310 --> 00:57:25.500
on the pipeline at least so we work with

1478
00:57:25.520 --> 00:57:26.770
both the agencies

1479
00:57:26.790 --> 00:57:29.570
in them prioritizing those and

1480
00:57:29.590 --> 00:57:31.810
definitely once the

1481
00:57:31.830 --> 00:57:34.290
this program evolves a little bit more i

1482
00:57:34.310 --> 00:57:35.570
will be glad to

1483
00:57:35.590 --> 00:57:37.810
in have interactions with them within

1484
00:57:37.830 --> 00:57:39.420
our

1485
00:57:39.440 --> 00:57:42.050
community outreach program at NIEHS and

1486
00:57:42.070 --> 00:57:43.740
with the environmental justice to see

1487
00:57:43.760 --> 00:57:46.050
how this information can be disseminated

1488
00:57:46.070 --> 00:57:48.220
to those communities for sure

1489
00:57:48.240 --> 00:57:51.420
thank you for that thank you and and dr

1490
00:57:51.440 --> 00:57:53.330
wright i will give you a

1491
00:57:53.350 --> 00:57:56.460
next to last question um

1492
00:57:56.480 --> 00:57:58.140
a great presentation and a very

1493
00:57:58.160 --> 00:57:59.740
interesting program so

1494
00:57:59.760 --> 00:58:01.090
i wanted to provide a clinical

1495
00:58:01.110 --> 00:58:03.420
perspective i'm actually a pediatric er

1496
00:58:03.440 --> 00:58:05.660
physician and i did a medical toxicology

1497
00:58:05.680 --> 00:58:07.420
fellowship so your presentation brought

1498
00:58:07.440 --> 00:58:07.980
back some

1499
00:58:08.000 --> 00:58:10.290
fond memories from 25 years ago when i

1500
00:58:10.310 --> 00:58:11.090
was training

1501
00:58:11.110 --> 00:58:14.530
it's pretty much the same agents but um

1502
00:58:14.550 --> 00:58:17.330
having said that it seems like one of

1503
00:58:17.350 --> 00:58:18.380
the big research

1504
00:58:18.400 --> 00:58:22.220
gaps is actually in diagnostics

1505
00:58:22.240 --> 00:58:24.860
um very few physicians would recognize

1506
00:58:24.880 --> 00:58:26.530
mustard gas poisoning very few

1507
00:58:26.550 --> 00:58:27.980
physicians would

1508
00:58:28.000 --> 00:58:30.530
know what chlorine does or what bromine

1509
00:58:30.550 --> 00:58:31.330
does

1510
00:58:31.350 --> 00:58:33.810
and how to treat it and i think there

1511
00:58:33.830 --> 00:58:36.140
should be some research i would argue in

1512
00:58:36.160 --> 00:58:36.940
that area

1513
00:58:36.960 --> 00:58:38.940
you know there may be diagnostic tests

1514
00:58:38.960 --> 00:58:41.090
maybe using untargeted methods

1515
00:58:41.110 --> 00:58:43.500
but also ambient sensors could be used a

1516
00:58:43.520 --> 00:58:45.330
lot of these agents stick to the clothes

1517
00:58:45.350 --> 00:58:46.940
and there's actually been cases that

1518
00:58:46.960 --> 00:58:47.570
people

1519
00:58:47.590 --> 00:58:49.900
working in the emergency room have been

1520
00:58:49.920 --> 00:58:51.900
had had secondary poisons

1521
00:58:51.920 --> 00:58:53.330
and also i think that would address

1522
00:58:53.350 --> 00:58:55.260
jalon's question to some extent because

1523
00:58:55.280 --> 00:58:58.140
if these are in uh waste sites you know

1524
00:58:58.160 --> 00:58:59.980
ambient sensors could help to alert

1525
00:59:00.000 --> 00:59:01.180
whether or not you know they're being

1526
00:59:01.200 --> 00:59:02.460
released so i

1527
00:59:02.480 --> 00:59:04.140
i would really urge the program to think

1528
00:59:04.160 --> 00:59:06.620
about diagnostics as well

1529
00:59:06.640 --> 00:59:08.700
i know it's too late for this particular

1530
00:59:08.720 --> 00:59:10.290
rfa

1531
00:59:10.310 --> 00:59:14.620
the through the dvod program we have

1532
00:59:14.640 --> 00:59:17.020
an efforts going on for a sense of

1533
00:59:17.040 --> 00:59:18.380
development for

1534
00:59:18.400 --> 00:59:21.420
assessing the exposure levels and

1535
00:59:21.440 --> 00:59:23.570
also some of the biomarkers some of the

1536
00:59:23.590 --> 00:59:25.660
biomarkers develop through our program

1537
00:59:25.680 --> 00:59:28.940
also for example chlorinated lipids

1538
00:59:28.960 --> 00:59:31.900
um that can stay in your system for

1539
00:59:31.920 --> 00:59:33.090
longer periods

1540
00:59:33.110 --> 00:59:35.260
as one of the markets for exposure to

1541
00:59:35.280 --> 00:59:36.530
chlorine

1542
00:59:36.550 --> 00:59:40.460
it's in developed by uh rakesh patel and

1543
00:59:40.480 --> 00:59:41.420
others

1544
00:59:41.440 --> 00:59:44.380
uab and it's still in the developmental

1545
00:59:44.400 --> 00:59:45.980
stages of some that is something

1546
00:59:46.000 --> 00:59:49.570
promising as a measure of exposure

1547
00:59:49.590 --> 00:59:53.090
on as a biomarker of exposure and

1548
00:59:53.110 --> 00:59:55.810
we definitely we have this interaction

1549
00:59:55.830 --> 00:59:56.140
with

1550
00:59:56.160 --> 00:59:59.740
all the agencies but um we have to do a

1551
00:59:59.760 --> 00:59:59.980
lot

1552
01:00:00.000 --> 01:00:02.050
more on the diagnostic things as you

1553
01:00:02.070 --> 01:00:03.900
suggested and we'll definitely take that

1554
01:00:03.920 --> 01:00:05.260
into consideration

1555
01:00:05.280 --> 01:00:08.530
thank you okay thank you um and our last

1556
01:00:08.550 --> 01:00:09.500
question is from dr

1557
01:00:09.520 --> 01:00:12.860
geller thank you uh thank you pat

1558
01:00:12.880 --> 01:00:14.220
and thank you sheree for that

1559
01:00:14.240 --> 01:00:16.940
presentation i just wanted to check or

1560
01:00:16.960 --> 01:00:19.570
offer um potential interaction with the

1561
01:00:19.590 --> 01:00:21.420
environmental protection agency we've

1562
01:00:21.440 --> 01:00:24.220
got a homeland security research program

1563
01:00:24.240 --> 01:00:26.530
and i'm sure you know our responsibility

1564
01:00:26.550 --> 01:00:27.980
is for for cleaning up

1565
01:00:28.000 --> 01:00:31.570
and remediating um for bio rad

1566
01:00:31.590 --> 01:00:34.700
uh chemical um uh

1567
01:00:34.720 --> 01:00:38.530
and nuclear materials um we do

1568
01:00:38.550 --> 01:00:41.810
look at contaminant characterization and

1569
01:00:41.830 --> 01:00:44.860
assessment so in terms of of identifying

1570
01:00:44.880 --> 01:00:46.860
those situations and the situations that

1571
01:00:46.880 --> 01:00:47.260
we've

1572
01:00:47.280 --> 01:00:48.860
put together and actually the

1573
01:00:48.880 --> 01:00:50.860
simulations that our homeland security

1574
01:00:50.880 --> 01:00:52.700
research program

1575
01:00:52.720 --> 01:00:56.220
runs may be really very very fertile

1576
01:00:56.240 --> 01:00:57.570
ground for thinking about

1577
01:00:57.590 --> 01:01:00.050
the the uh the medical and biomedical

1578
01:01:00.070 --> 01:01:01.740
responses that you're thinking of

1579
01:01:01.760 --> 01:01:04.380
we really think mostly in terms of our

1580
01:01:04.400 --> 01:01:06.290
physical responses

1581
01:01:06.310 --> 01:01:09.330
and cleanup responses um working

1582
01:01:09.350 --> 01:01:11.180
and and drawing in these biomedical

1583
01:01:11.200 --> 01:01:13.660
approaches would be a i think a great uh

1584
01:01:13.680 --> 01:01:16.220
a great opportunity so thank you and

1585
01:01:16.240 --> 01:01:17.570
look forward to working with you

1586
01:01:17.590 --> 01:01:19.260
yeah definitely i'll be in touch with

1587
01:01:19.280 --> 01:01:20.770
you andy

1588
01:01:20.790 --> 01:01:23.090
and sure you have a question from doctor

1589
01:01:23.110 --> 01:01:24.940
from shipment hoe in that oh and it just

1590
01:01:24.960 --> 01:01:25.500
went away

1591
01:01:25.520 --> 01:01:28.860
um about open where did it go well open

1592
01:01:28.880 --> 01:01:29.740
tip burning

1593
01:01:29.760 --> 01:01:31.660
exposure be included if you can give us

1594
01:01:31.680 --> 01:01:33.020
a quick answer that then we can kind of

1595
01:01:33.040 --> 01:01:34.050
move on to our vote

1596
01:01:34.070 --> 01:01:38.220
um i may not be in this program because

1597
01:01:38.240 --> 01:01:40.380
this is more focused on the

1598
01:01:40.400 --> 01:01:42.340
chemicals identified through them

1599
01:01:42.360 --> 01:01:43.420
[Music]

1600
01:01:43.440 --> 01:01:49.980
etc

1601
01:01:50.000 --> 01:01:53.570
okay um i'm looking at the uh

1602
01:01:53.590 --> 01:01:55.500
i'm gonna in the interest of time i'm

1603
01:01:55.520 --> 01:01:56.860
gonna go ahead and move us to a vote i

1604
01:01:56.880 --> 01:01:58.860
would suggest that people look on the

1605
01:01:58.880 --> 01:02:01.180
the chat especially dr young has

1606
01:02:01.200 --> 01:02:03.660
provided some explanation about the uh

1607
01:02:03.680 --> 01:02:06.050
from the toxicity availability and such

1608
01:02:06.070 --> 01:02:06.700
and so

1609
01:02:06.720 --> 01:02:10.050
um at this point i want to thank um

1610
01:02:10.070 --> 01:02:12.700
doctors kavanaugh and penny and i will

1611
01:02:12.720 --> 01:02:13.260
ask

1612
01:02:13.280 --> 01:02:15.420
for a and tell people if they have more

1613
01:02:15.440 --> 01:02:16.620
questions they can contact sheree

1614
01:02:16.640 --> 01:02:17.810
directly or put them in the chat and

1615
01:02:17.830 --> 01:02:19.420
shriek and respond that way

1616
01:02:19.440 --> 01:02:22.380
i'm going to ask for a motion to approve

1617
01:02:22.400 --> 01:02:24.530
this concept to go forward

1618
01:02:24.550 --> 01:02:28.620
i've got a motion they'll have a second

1619
01:02:28.640 --> 01:02:30.700
they've got a second any discussion for

1620
01:02:30.720 --> 01:02:32.140
the discussion or

1621
01:02:32.160 --> 01:02:36.770
debate if not i will ask you to

1622
01:02:36.790 --> 01:02:38.940
go into your electronic council book and

1623
01:02:38.960 --> 01:02:41.330
vote

1624
01:02:41.350 --> 01:02:47.320
for this concept

1625
01:02:47.340 --> 01:02:50.530


1626
01:02:50.550 --> 01:02:52.290
and liz you will let me know when we

1627
01:02:52.310 --> 01:02:53.810
have

1628
01:02:53.830 --> 01:02:59.800
achieved our goal

1629
01:02:59.820 --> 01:03:14.810


1630
01:03:14.830 --> 01:03:16.860
okay

1631
01:03:16.880 --> 01:03:19.570
okay okay looks like we're there and i

1632
01:03:19.590 --> 01:03:20.290
assume that

1633
01:03:20.310 --> 01:03:23.980
that was approved is we have our voting

1634
01:03:24.000 --> 01:03:25.420
approval okay congratulations shari

1635
01:03:25.440 --> 01:03:26.530
thank you very much

1636
01:03:26.550 --> 01:03:28.380
and thank you all for a um for a very

1637
01:03:28.400 --> 01:03:29.980
nice discussion there again

1638
01:03:30.000 --> 01:03:31.980
i recommend that people go into the chat

1639
01:03:32.000 --> 01:03:33.570
uh and and look we have a question from

1640
01:03:33.590 --> 01:03:34.050
dr

1641
01:03:34.070 --> 01:03:35.980
tangway too that shri you may want to

1642
01:03:36.000 --> 01:03:37.180
address that

1643
01:03:37.200 --> 01:03:40.860
as well i will look into the chat

1644
01:03:40.880 --> 01:03:44.380
thanks sir um we're now um

1645
01:03:44.400 --> 01:03:46.860
scheduled for a quick 15 minute grab

1646
01:03:46.880 --> 01:03:48.530
your lunch and come back break

1647
01:03:48.550 --> 01:03:50.770
um why don't we try to get back here at

1648
01:03:50.790 --> 01:03:51.740
1205

1649
01:03:51.760 --> 01:03:54.140
give us our full 15 minutes at which

1650
01:03:54.160 --> 01:03:56.770
time dr woychik will will give his um

1651
01:03:56.790 --> 01:03:59.570
his report of the director followed by

1652
01:03:59.590 --> 01:04:00.460
um

1653
01:04:00.480 --> 01:04:02.940
some interesting um an interesting

1654
01:04:02.960 --> 01:04:04.940
presentation from our division of

1655
01:04:04.960 --> 01:04:07.660
national tax ecology program um dr

1656
01:04:07.680 --> 01:04:09.740
watson did you say anything before we

1657
01:04:09.760 --> 01:04:12.220
take our break no i just thank everyone

1658
01:04:12.240 --> 01:04:14.050
for the morning session

1659
01:04:14.070 --> 01:04:17.906
and let's get back here in 15 minutes